Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.
Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.
复制标题
Lyt 表型的意义：Lyt2 抗体可阻断识别 1 类主要组织相容性复合体抗原的 T 细胞的活性，无论其功能如何。
DOI：
10.1073/pnas.78.11.7101
复制
发表时间：
1981
影响因子：
11.1
通讯作者：
Swain,SL
中科院分区：
文献类型：
--
作者：
Swain,SL
抗Lyt 2对辅助性T细胞功能的产生和对主要组织相容性复合体（MHC）亚区特异性细胞毒性作用的影响进行了测定。当应答针对同种异体1类MHC抗原（小鼠H-2复合物的K和D基因产物）时，向体外培养物中加入不含补体的抗Lyt 2阻断了同种异体MHC诱导的辅助和淋巴因子产生以及细胞毒性效应的产生，但当这些应答对2类MHC抗原（I区基因产物）具有特异性时，则无影响。抗Lyt 2未能阻止响应的帮助诱导同种异体混合淋巴细胞刺激决定簇或产生的淋巴因子的T细胞特异性1类MHC抗原时，刀豆球蛋白A凝集素被用来诱导活动。这些和早期的结果表明，抗Lyt 2抗血清阻断功能的能力与T细胞对1类MHC抗原的特异性相关，而与细胞的功能活性无关。
The effect of anti-Lyt2 on the generation of helper T-cell function and on cytotoxic effects specific for subregions of the major histocompatibility complex (MHC) was determined. The addition of anti-Lyt2 without complement to in vitro cultures blocked the generation of allogeneic MHC-induced help and lymphokine production and cytotoxic effects when the response was directed against allogeneic class 1 MHC antigens (K and D gene products of the mouse H-2 complex) but had no effect when these responses were specific for class 2 MHC antigens (I region gene products). Anti-Lyt2 failed to block the response of help induced to allogeneic mixed lymphocyte-stimulating determinants or the production of lymphokines by T cells specific for class 1 MHC antigens when concanavalin A lectin was used to induce activity. These and earlier results indicate that the ability of anti-Lyt2 antisera to block function is correlated with T cell specificity for class 1 MHC antigens not with the functional activity of the cells.