Pharmaceutical Film Coating Catalog for Spectral Domain Optical Coherence Tomography
Pharmaceutical Film Coating Catalog for Spectral Domain Optical Coherence Tomography
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DOI：
10.1016/j.xphs.2017.05.032
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发表时间：
2017-10-01
影响因子：
3.8
通讯作者：
Zeitler, J. Axel
中科院分区：
文献类型：
--
作者：
Lin, Hungyen;Dong, Yue;Zeitler, J. Axel
光学相干断层扫描（OCT）最近已被证明可以直接测量药物片剂和微丸的薄膜包衣厚度。这些结果使得能够在离线和在线设置下分析片剂间和片剂内包衣的变异性。到目前为止，只有少数涂料配方已被尝试，有非常少的信息OCT的适用性，以其他涂料。由于有充分的文献证明，包括OCT在内的光学方法易于散射，导致穿透有限，因此某些药物涂层可能无法完全测量。本研究提供了22种不同常见涂层的OCT测量值，用于评估OCT适用性。(C)2017作者爱思唯尔公司出版美国药学协会（American Pharmacopoeia Association）（R）这是一个在CC BY许可证下的开放获取文章（http：//creativecommons.org/licenses/by/4.0/）。
Optical coherence tomography (OCT) has recently been demonstrated to measure the film coating thickness of pharmaceutical tablets and pellets directly. The results enable the analysis of inter-and intra-tablet coating variability at an off-line and in-line setting. To date, only a few coating formulations have been tried and there is very little information on the applicability of OCT to other coatings. As it is well documented that optical methods including OCT are prone to scattering leading to limited penetration, some pharmaceutical coatings may not be measurable altogether. This study presents OCT measurements of 22 different common coatings for the assessment of OCT applicability. (C) 2017 The Authors. Published by Elsevier Inc. on behalf of the American Pharmacists Association (R). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).