Serum levels of interleukin 15 in patients with rheumatic diseases.
Serum levels of interleukin 15 in patients with rheumatic diseases.
复制标题
风湿病患者血清白介素 15 水平。
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
H. Hashimoto
中科院分区：
文献类型：
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作者：
J. Suzuki;S. Morimoto;H. Amano;Y. Tokano;Y. Takasaki;H. Hashimoto
客观的
OBJECTIVE
The role of the cytokine interleukin 15 (IL-15) in rheumatic disease is unclear. We examined serum levels of IL-15 in patients with various rheumatic diseases.
METHODS
Serum levels of IL-15 were determined by sandwich ELISA.
RESULTS
Serum levels of IL-15 were significantly increased in patients with polymyositis/dermatomyositis, polyarteritis nodosa, and systemic sclerosis; and significantly increased as well in disease complicated by interstitial pneumonitis (IP), hemophagocytic syndrome (HPS), and/or vasculitis. Patients with serum IL-15 levels < or = 5 pg/ml showed significantly high rates of survival.
CONCLUSION
IL-15 is related to the pathogenesis of IP, HPS, and/or vasculitis. Serum IL-15 level could possibly be used as a marker of prognosis.