DECREASED GRAY-MATTER IN NORMAL AGING - AN INVIVO MAGNETIC-RESONANCE STUDY
DECREASED GRAY-MATTER IN NORMAL AGING - AN INVIVO MAGNETIC-RESONANCE STUDY
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DOI：
10.1093/geronj/47.1.b26
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发表时间：
1992-01-01
期刊：
影响因子：
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通讯作者：
PFEFFERBAUM, A
中科院分区：
文献类型：
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作者：
LIM, KO;ZIPURSKY, RB;PFEFFERBAUM, A
采用活体磁共振（MR）成像技术，对8名青年和6名老年正常男性社区志愿者的脑灰质、白质和脑脊液（CSF）的百分比进行了量化。与年轻男性相比，老年男性的灰质百分比显著降低（p < 0.01），脑脊液百分比显著升高（p < 0.01）。两组间脑白质比例无显著差异。这一发现表明，与年龄相关的脑组织减少主要是由于灰质的损失。
Using in vivo magnetic resonance (MR) images, the percentages of gray matter, white matter, and cerebrospinal fluid (CSF) in the brains of 8 young and 6 elderly normal male community volunteers were quantified. Compared with the young men, the elderly men had a significantly lower percentage of gray matter (p < .01) and higher percentage of CSF (p < .01). The percentage of white matter was not significantly different between the two groups. This finding suggests that the age-related decrease in brain tissue is chiefly due to loss of gray matter.