PASSIVE MECHANICAL-PROPERTIES OF HUMAN-LEUKOCYTES
PASSIVE MECHANICAL-PROPERTIES OF HUMAN-LEUKOCYTES
复制标题
DOI：
10.1016/s0006-3495(81)84726-1
复制
发表时间：
1981-01-01
影响因子：
3.4
通讯作者：
CHIEN, S
中科院分区：
文献类型：
--
作者：
SCHMIDSCHONBEIN, GW;SUNG, KLP;CHIEN, S
微量吸液管实验用于确定人白细胞的流变学特性。通过微量移液管使EDTA中的单个细胞经受已知的抽吸压力，并且在电视监视器上记录它们从未变形的球形的表面变形。细胞在数学上被建模为均匀的球体，并且标准的固体粘弹性模型准确地描述了细胞在小应变下的变形。这些实验和理论研究为健康和疾病中白细胞流变学的进一步研究提供了基础。
Micropipette experiments are used to determine the rheological properties of human leukocytes. Individual cells in EDTA are subjected to a known aspiration pressure via a micropipette, and their surface deformation from the undeformed spherical shape is recorded on a television monitor. The cells are mathematically modeled as homogeneous spheres, and a standard solid viscoelastic model describes accurately the deformation of the cell for small strains. These experimental and theoretical studies provide the basis for further investigations of leukocyte rheology in health and disease.