Rapid multicomponent relaxometry in steady state with correction of magnetization transfer effects.
Rapid multicomponent relaxometry in steady state with correction of magnetization transfer effects.
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DOI：
10.1002/mrm.25672
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发表时间：
2016-04
影响因子：
3.3
通讯作者：
Samsonov A
中科院分区：
文献类型：
--
作者：
Liu F;Block WF;Kijowski R;Samsonov A
To study the effects of magnetization transfer (MT) on multi-component T2 parameters obtained using mcDESPOT in macromolecule-rich tissues and to propose a new method called mcRISE to correct MT-induced biases. The two-pool mcDESPOT model was modified by the addition of an exchanging macromolecule proton pool to model the MT effect in cartilage. An mcRISE acquisition scheme was developed to provide sensitivity to all pools. An incremental fitting was applied to estimate MT and relaxometry parameters with minimized coupling. The interaction between MT and relaxometry parameters, efficacy of MT correction, and feasibility of mcRISE in-vivo were investigated in simulations and in healthy volunteers. The MT effect caused significant errors in multi-component T1/T2 values and in fast-relaxing water fraction fF, which is consistent with previous experimental observations. fF increased significantly with macromolecule content if MT was ignored. mcRISE resulted in a multi-fold reduction of MT biases and yielded decoupled multi-component T1/T2 relaxometry and quantitative MT parameters. mcRISE is an efficient approach for correcting MT biases in multi-component relaxometry based on steady-state sequences. Improved specificity of mcRISE may help to elucidate the sources of the previously described high sensitivity of non-corrected mcDESPOT parameters to disease-related changes in cartilage and brain.
