Lysophospholipid receptors in the nervous system
Lysophospholipid receptors in the nervous system
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DOI：
10.1023/a:1020219915922
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发表时间：
2002-08-01
影响因子：
4.4
通讯作者：
Spiegel, S
中科院分区：
文献类型：
--
作者：
Toman, RE;Spiegel, S
溶血磷脂介质，溶血磷脂酸（LPA）和鞘氨醇-1-磷酸（S1 P），是负责细胞信号转导的不同途径，包括生存，增殖，运动和分化。大多数这种信号传导通过一个八成员的G蛋白偶联受体家族发生，该家族曾被称为内皮分化基因（EDG）家族。最近，EDG受体被分为两个亚家族：溶血磷脂酸亚家族，包括LPA（1），（EDG-2/VZG-1）、LPA（2）（EDG-4）和LPA（3）（EDG-7），以及鞘氨醇-1-磷酸受体亚家族，其包括S1 P（1）（EDG-1）、S1 P（2）（EDG-4）和S1 P（3）（EDG-7）。（EDG-5/H218/AGR16）、S1P（3）（EDG-3）、S1P（4）（EDG-6）和S1P（5）（EDG-8/NRG-1）。这些受体在不同物种中无处不在的表达，加上它们不同的细胞功能，使溶血磷脂受体成为信号转导研究的重要焦点。神经科学家最近开始探索溶血磷脂受体在许多细胞类型中的作用;这项研究表明这些受体与哺乳动物神经系统细胞的存活、迁移和分化有关。
The lysophospholipid mediators, lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P), are responsible for cell signaling in diverse pathways including survival, proliferation, motility, and differentiation. Most of this signaling occurs through an eight-member family of G-protein coupled receptors once known as the endothelial differentiation gene (EDG) family. More recently, the EDG receptors have been divided into two subfamilies: the lysophosphatidic acid subfamily, which includes LPA(1), (EDG-2/VZG-1), LPA(2) (EDG-4), and LPA(3) (EDG-7), and the sphingosine-1-phosphate receptor subfamily, which includes S1P(1) (EDG-1), S1P(2) (EDG-5/H218/AGR16), S1P(3) (EDG-3), S1P(4) (EDG-6), and S1P(5) (EDG-8/NRG-1). The ubiquitous expression of these receptors across species, coupled with their diverse cellular functions, has made lysophospholipid receptors an important focus of signal transduction research. Neuroscientists have recently begun to explore the role of lysophospholipid receptors in a number of cell types; this research has implicated these receptors in the survival, migration, and differentiation of cells in the mammalian nervous system.