Spatially Quantifying Microscopic Tumor Invasion and Proliferation Using a Voxel-Wise Solution to a Glioma Growth Model and Serial Diffusion MRI
Spatially Quantifying Microscopic Tumor Invasion and Proliferation Using a Voxel-Wise Solution to a Glioma Growth Model and Serial Diffusion MRI
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DOI：
10.1002/mrm.22688
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发表时间：
2011-04-01
影响因子：
3.3
通讯作者：
Schmainda, Kathleen M.
中科院分区：
文献类型：
--
作者：
Ellingson, Benjamin M.;LaViolette, Peter S.;Schmainda, Kathleen M.
本研究的目的是开发一个逐体素的分析解决方案，胶质瘤生长模型，使用串行扩散MRI。这些细胞侵袭、运动和增殖水平估计（CIMPLE图）提供了微观肿瘤生长动力学的定量估计。在找到解析解后，进行噪声模拟以预测表观扩散系数值的扰动和表观扩散系数图采集之间的时间对CIMPLE图的准确性的影响。然后为53例WHO分级为II-IV级的胶质瘤患者创建CIMPLE图。使用Pearson相关分析，将胆碱与N-乙酰天冬氨酸比率的MR波谱估计值与CIMPLE图中的细胞增殖估计值进行比较。比较WHO分级之间细胞增殖和扩散率的中位差异。一个强相关性（R-2 = 0.9714）和良好的空间对应性之间观察到的MR波谱测量胆碱-N-乙酰天冬氨酸比和CIMPLE地图细胞增殖率估计。低级别（WHO II）和高级别（WHO III-IV）胶质瘤之间的细胞增殖和扩散速率估计值似乎存在显著差异。细胞扩散速率（运动性）估计高度依赖于表观扩散系数图采集之间的时间间隔，而细胞增殖速率估计还受到表观扩散系数图中存在的噪声水平的影响。Magn Reson Med 65：1132 - 1144，2011. (C)2010 Wiley-Liss，Inc.
The purpose of this study was to develop a voxel-wise analytical solution to a glioma growth model using serial diffusion MRI. These cell invasion, motility, and proliferation level estimates (CIMPLE maps) provide quantitative estimates of microscopic tumor growth dynamics. After an analytical solution was found, noise simulations were performed to predict the effects that perturbations in apparent diffusion coefficient values and the time between apparent diffusion coefficient map acquisitions would have on the accuracy of CIMPLE maps. CIMPLE maps were then created for 53 patients with gliomas with WHO grades of II-IV. MR spectroscopy estimates of the choline-to-N-acetylaspartate ratio were compared to cell proliferation estimates in CIMPLE maps using Pearson's correlation analysis. Median differences in cell proliferation and diffusion rates between WHO grades were compared. A strong correlation (R-2 = 0.9714) and good spatial correspondence were observed between MR spectroscopy measurements of the choline-to-N-acetylaspartate ratio and CIMPLE map cell proliferation rate estimates. Estimates of cell proliferation and diffusion rates appear to be significantly different between low- (WHO II) and high-grade (WHO III-IV) gliomas. Cell diffusion rate (motility) estimates are highly dependent on the time interval between apparent diffusion coefficient map acquisitions, whereas cell proliferation rate estimates are additionally influenced by the level of noise present in apparent diffusion coefficient maps. Magn Reson Med 65: 1132-1144, 2011. (C) 2010 Wiley-Liss, Inc.