Reversible leukoencephalopathy associated with cerebral amyloid angiopathy
Reversible leukoencephalopathy associated with cerebral amyloid angiopathy
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DOI：
10.1212/01.wnl.0000106951.94624.df
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发表时间：
2004-02-10
期刊：
影响因子：
9.9
通讯作者：
Elkind, MSV
中科院分区：
文献类型：
--
作者：
Oh, U;Gupta, R;Elkind, MSV
作者描述了三例可逆性白质脑病与脑淀粉样血管病（CAA）。神经系统症状的快速进展，随后是戏剧性的临床和影像学改善。病理学上，CAA与不同程度的炎症相关，从无炎症到透壁肉芽肿浸润。在适当的临床背景下，MRI发现脑叶白色水肿伴既往含铁血黄素沉积的证据可能表明存在可逆性CAA白质脑病。
The authors describe three patients with reversible leukoencephalopathy associated with cerebral amyloid angiopathy (CAA). Rapid progression of neurologic symptoms was followed by dramatic clinical and radiographic improvement. Pathologically, CAA was associated with varying degrees of inflammation ranging from none to transmural granulomatous infiltration. In the appropriate clinical context, the MRI finding of lobar white matter edema with evidence of prior hemosiderin deposition may indicate the presence of a reversible CAA leukoencephalopathy.