The Relationship Between Oseltamivir and Suicide in Pediatric Patients
The Relationship Between Oseltamivir and Suicide in Pediatric Patients
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DOI：
10.1370/afm.2183
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发表时间：
2018-03-01
影响因子：
4.4
通讯作者：
Antoon, James W.
中科院分区：
文献类型：
--
作者：
Harrington, Rachel;Adimadhyam, Sruthi;Antoon, James W.
研究儿童使用奥司他韦与神经精神事件（包括自杀）之间的关系，研究结果喜忧参半，并受到样本量小、依赖旧数据和潜在混杂因素的限制。我们进行了一项针对这些局限性的分析。方法使用国家行政索赔数据库和病例交叉设计，最大限度地减少混淆，我们分析了5个当代流感季节的数据（2009-2013），年龄在1至18岁的个人，并确定奥司他韦暴露于药房配药。结果我们确定了21,407自杀相关事件在本研究期间，其中251例为接触奥司他韦的儿童。在病例交叉分析中，我们没有发现奥司他韦暴露与自杀有任何显著关联（比值比= 0.64; 95% CI，0.39-1.00; P = 0.05）或仅流感诊断（比值比= 0.63; 95%CI，0.34-1.08; P = 0.10）.结论我们的研究结果表明，奥司他韦不会增加儿童人群的自杀风险。
PURPOSE Studies examining the association between use of oseltamivir and neuropsychiatric events (including suicide) among children have had mixed findings and have been limited by small sample size, reliance on older data, and potential confounding. We undertook an analysis that addresses these limitations.METHODS Using a national administrative claims database and a case-crossover design that minimized confounding, we analyzed data from 5 contemporary influenza seasons (2009-2013) for individuals aged 1 to 18 years and ascertained oseltamivir exposure from pharmacy dispensing.RESULTS We identified 21,407 suicide-related events during this study period, 251 of which were in oseltamivir-exposed children. In case-crossover analysis, we did not find any significant association with suicide either for oseltamivir exposure (odds ratio = 0.64; 95% CI, 0.39-1.00; P =.05) or for influenza diagnosis alone (odds ratio = 0.63; 95% CI, 0.34-1.08; P =.10).CONCLUSION Our findings suggest that oseltamivir does not increase risk of suicide in the pediatric population.