The effect of ascorbic acid supplementation on endosulfan toxicity in rabbits
The effect of ascorbic acid supplementation on endosulfan toxicity in rabbits
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补充抗坏血酸对家兔硫丹毒性的影响
DOI：
10.1177/0748233710388450
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发表时间：
2011
影响因子：
1.9
通讯作者：
S. Ozdem
中科院分区：
文献类型：
--
作者：
S. Ozdem;Cahit Nacitarhan;M. Gulay;F. Hatipoğlu;S. Ozdem
我们研究了硫丹引起的家兔氧化应激和抗氧化能力的血清生化标志物的变化以及补充维生素C对硫丹引起的家兔氧化应激和抗氧化能力的变化的影响。对连续6周单独服用硫丹（1毫克/千克）或同时服用维生素C（20毫克/千克）的家兔，测量了基础、第4周和第6周血清中总氧化状态、硫代巴比妥酸反应物质、晚期氧化蛋白产物、总抗氧化能力、总蛋白巯基和谷胱甘肽-S-转移酶的水平。对照兔接受溶剂或维生素C。在第4周和第6周，硫丹给药家兔的血清TOS、TBARS和AOPP水平显著高于基础值，而T-SH水平显著低于基础值。GST在第4周显著升高，但在第6周降至基础值以下。同样，TAC在6周时显著降低。补充维生素C增加了对照组第4周和第6周的总抗氧化能力，增加了硫丹给药组第4周的T-SH和GST，降低了TOS、TBARS和AOPP。在第6周，补充维生素C后，硫丹给药家兔的总抗氧化能力显著增加。与第4周相比，硫丹给药兔第6周TBARS显著增加，TAC和GST水平显著降低。目前的研究结果表明，在服用硫丹的兔子中，氧化应激增加并逐渐失去补偿，补充维生素C可通过提高抗氧化能力大大改善这种应激。有人建议，补充维生素C可能有助于预防硫丹暴露导致的氧化应激增加的有害影响。
We investigated the endosulfan-induced alterations and the effect of vitamin C supplementation on endosulfan-induced alterations in serum biochemical markers of oxidative stress and antioxidant capacity in rabbits. Basal, 4th and 6th week serum levels of total oxidant status (TOS), thiobarbituric acid reactive substances (TBARS), advanced oxidation protein products (AOPP), total antioxidant capacity (TAC), total protein sulfhydryl (T-SH) and glutathione-S-transferase (GST) were measured in rabbits administered endosulfan (1 mg/kg) alone or in combination with vitamin C (20 mg/kg) for 6 weeks. Control rabbits received either vehicles or vitamin C. Serum TOS, TBARS and AOPP levels at 4th and 6th week were significantly higher whereas T-SH levels were significantly lower than basal values in endosulfan-administered rabbits. GST increased significantly at 4th week but decreased below basal value at 6th week. Similarly, TAC decreased significantly at 6th week. Vitamin C supplementation increased TAC at 4th and 6th weeks in controls and increased T-SH and GST and decreased TOS, TBARS and AOPP at 4th week in endosulfan-administered rabbits. TAC increased significantly at 6th week by vitamin C supplementation in endosulfan-administered rabbits. There were significant increments in TBARS and decrements in TAC and GST levels at 6th week compared to 4th week in endosulfan-administered rabbits. Present findings indicated to an increased and progressively uncompensated oxidant stress in endosulfan-administered rabbits that was substantially ameliorated by vitamin C supplementation through an improvement in antioxidant capacity. It was suggested that vitamin C supplementation might be helpful in preventing the detrimental effects of increased oxidative stress caused by endosulfan exposure.
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影响因子：
19.6
作者：
WitkoSarsat, V;Friedlander, M;DescampsLatscha, B
通讯作者：
DescampsLatscha, B
TCDD、异狄氏剂和林丹诱导 C57BL/6J 和 DBA/2J 小鼠胎儿和胎盘组织的氧化应激。
DOI：
10.1016/s0742-8413(96)00116-8
发表时间：
1996
期刊：
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology
影响因子：
--
作者：
Hassoun,EA;Stohs,SJ
通讯作者：
Stohs,SJ
影响因子：
7.4
作者：
Landar, A;Oh, JY;Darley-Usmar, VM
通讯作者：
Darley-Usmar, VM
根据人类的抗氧化和健康影响，制定新的维生素 C 膳食摄入量建议。
DOI：
10.1093/ajcn/69.6.1086
发表时间：
1999
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Carr,AC;Frei,B
通讯作者：
Frei,B
狄氏剂/毒杀芬混合物在小鼠子宫、MCF-7 人乳腺癌细胞和酵母雌激素受体测定中的雌激素活性：无明显协同作用。
DOI：
10.1210/endo.138.4.5056
发表时间：
1997
期刊：
Endocrinology.
影响因子：
--
作者：
Ramamoorthy,K;Wang,F;Chen,IC;Norris,JD;McDonnell,DP;Leonard,LS;Gaido,KW;Bocchinfuso,WP;Korach,KS;Safe,S
通讯作者：
Safe,S