The role of the SHH gene in prostate cancer cell resistance to paclitaxel
The role of the SHH gene in prostate cancer cell resistance to paclitaxel
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DOI：
10.1002/pros.22830
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发表时间：
2014-08
期刊：
影响因子：
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通讯作者：
M. Statkiewicz;Natalia Maryan;A. Lipiec;E. Grecka;M. Grygorowicz;Marcin Omiotek;Agnieszka E. Gorska;M. Mikuła;M. Małecki
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文献类型：
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作者：
M. Statkiewicz;Natalia Maryan;A. Lipiec;E. Grecka;M. Grygorowicz;Marcin Omiotek;Agnieszka E. Gorska;M. Mikuła;M. Małecki
已在包括前列腺癌（PCa）在内的许多类型的癌症中证明了Sonic Hedgehog（SHH）途径的活性增加。研究表明，SHH通路参与肿瘤血管生成和肿瘤干细胞代谢的调节。SHH通路活性的增加是癌细胞多药耐药性产生和维持的原因。ATP结合盒（ABC）转运蛋白在这种对细胞毒性药物不敏感性的发展中起着关键作用。
The increased activity of the Sonic Hedgehog (SHH) pathway has been demonstrated in many types of cancer including prostate cancer (PCa). It has been shown that SHH pathway is involved in tumor angiogenesis and in regulation of metabolism of cancer stem cells. The increased activity of the SHH pathway is responsible for generation and maintenance of the multidrug resistance in cancer cells. A key role in the development of this insensitivity to cytotoxic drugs play ATP‐binding cassette (ABC) transporters.