Genotype- and experience-dependent susceptibility to depressive-like responses in the forced-swimming test
Genotype- and experience-dependent susceptibility to depressive-like responses in the forced-swimming test
复制标题
DOI：
10.1007/s00213-002-1161-8
复制
发表时间：
2002-11-01
影响因子：
3.4
通讯作者：
Puglisi-Allegra, S
中科院分区：
文献类型：
--
作者：
Alcaro, A;Cabib, S;Puglisi-Allegra, S
原理：强迫游泳测试（FST）被用来重现被动应对压力的反应，这可能是啮齿动物中人类抑郁的一个相关方面的模型。对FST表现出高水平被动反应的动物被认为是病态抑郁个体的模型。目的：我们评估fst诱导的行为反应对遗传和环境影响相互作用的敏感性。方法：观察C57BL/6和DBA/2两株小鼠对FST的行为反应，两株小鼠在试验前14天预先暴露于FST，经历过FST的小鼠随后暴露于12天的应激体验（食物限制）。结果：C57BL/6小鼠在FST中具有较高的被动应对倾向。此外，应激增强了C57BL/6小鼠的fst诱导的不动性，但降低了DBA/2小鼠的这种反应。最后，通过临床有效的抗抑郁药物慢性治疗，fst诱导的C57BL/6小鼠的不动能力减少。结论：这些结果支持C57BL/6小鼠对FST的行为和神经反应可用于抑郁症的临床前研究。
Rationale: The forced-swimming test (FST) is utilized to reproduce passive coping responses to stress that may model a relevant aspect of human depression in rodent species. Animals showing high levels of passive responses to the FST are assumed to model pathologically depressed individuals. Objectives: We evaluated sensitivity of FST-induced behavioral responses to the interaction between genetic and environmental influences. Methods: Behavioral responses to FST were evaluated in naive mice of the C57BL/6 and DBA/2 strains, in mice of both strains pre-exposed to FST 14 days before test, and in FST-experienced animals subsequently exposed to 12 days of stress experience (food restriction). Results: C57BL/6 mice are characterized by high propensity to adopt passive coping responses in the FST. Moreover, stress enhances FST-induced immobility in mice of the C57BL/6 strain but reduces this response in DBA/2 mice. Finally, FST-induced immobility in C57BL/6 mice is reduced by chronic treatment with clinically effective antidepressants. Conclusions: These results support the view that behavioral and neural responses to FST exhibited by C57BL/6 mice can be usefully exploited by pre-clinical research on depression.