Timing of initiation, patterns of breastfeeding, and infant survival: prospective analysis of pooled data from three randomised trials
Timing of initiation, patterns of breastfeeding, and infant survival: prospective analysis of pooled data from three randomised trials
复制标题
DOI：
10.1016/s2214-109x(16)00040-1
复制
发表时间：
2016-04-01
影响因子：
34.3
通讯作者：
Bahl, Rajiv
中科院分区：
文献类型：
--
作者：
Edmond, Karen;Newton, Sam;Bahl, Rajiv
背景虽然纯母乳喂养对儿童健康和生存的益处，特别是在新生儿后期，已经确定，但早期开始母乳喂养的独立有益影响仍不清楚。我们研究了母乳喂养开始的时间与入学后新生儿和6个月内新生儿死亡率之间的关系，以及母乳喂养模式与死亡率之间的关系。（入组28天）和6个月龄（29-180天）的新生儿后期死亡率，来自加纳、印度和坦桑尼亚的三项新生儿维生素A试验的大型队列。如果新生儿的母亲报告他们可能在未来6个月内留在研究区域，他们可以口服喂养，年龄小于3天，并且主要照顾者给予知情同意，则新生儿有资格参加这些试验。我们排除了在96小时后开始母乳喂养、未开始母乳喂养或未开始母乳喂养的婴儿。我们汇总了三项试验的两个随机分组的数据，然后将母乳喂养开始的时间分类为：
Background Although the benefits of exclusive breastfeeding for child health and survival, particularly in the post-neonatal period, are established, the independent beneficial effect of early breastfeeding initiation remains unclear. We studied the association between timing of breastfeeding initiation and post-enrolment neonatal and postneonatal mortality up to 6 months of age, as well as the associations between breastfeeding pattern and mortality.Methods We examined associations between timing of breastfeeding initiation, post-enrolment neonatal mortality (enrolment 28 days), and post-neonatal mortality up to 6 months of age (29-180 days) in a large cohort from three neonatal vitamin A trials in Ghana, India, and Tanzania. Newborn babies were eligible for these trials if their mother reported that they were likely to stay in the study area for the next 6 months, they could feed orally, were aged less than 3 days, and the primary caregiver gave informed consent. We excluded infants who initiated breastfeeding after 96 h, did not initiate, or had missing initiation status. We pooled the data from both randomised groups of the three trials and then categorised time of breastfeeding initiation as: at