INHIBITION OF GLYCOGEN-SYNTHASE KINASE-3 BY INSULIN IN CULTURED HUMAN SKELETAL-MUSCLE MYOBLASTS
INHIBITION OF GLYCOGEN-SYNTHASE KINASE-3 BY INSULIN IN CULTURED HUMAN SKELETAL-MUSCLE MYOBLASTS
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DOI：
10.1006/bbrc.1995.1721
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发表时间：
1995-05-25
影响因子：
3.1
通讯作者：
YEAMAN, SJ
中科院分区：
文献类型：
--
作者：
BORTHWICK, AC;WELLS, AM;YEAMAN, SJ
在大鼠L 6肌细胞系和培养的人成肌细胞中研究了胰岛素对糖原合成酶激酶3（GSK-3）活性的急性作用。GSK-3的α和β同种型存在于两种细胞类型中，β同种型在人细胞中占主导地位，胰岛素引起两种细胞系中两种同种型的快速失活，在人成肌细胞中观察到50%的失活。(C)出版社：Academic Press
The acute effects of insulin on the activity of glycogen synthase kinase 3 (GSK-3) have been investigated both in the rat L6 muscle cell line and in cultured human myoblasts, The alpha and beta isoforms of GSK-3 are present in both cell types,with the beta isoform being predominant in the human cells, insulin causes a rapid inactivation of both isoforms in both cell lines, with 50% inactivation being observed in the human myoblasts. (C) 1995 Academic Press, Inc.