Variations in the Prevalence of Metabolic Syndrome in Adolescents According to Different Criteria Used for Diagnosis: Which Definition Should Be Chosen for This Age Group?
Variations in the Prevalence of Metabolic Syndrome in Adolescents According to Different Criteria Used for Diagnosis: Which Definition Should Be Chosen for This Age Group?
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DOI：
10.1089/met.2013.0127
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发表时间：
2014-05-01
影响因子：
2.1
通讯作者：
Velasquez, Claudia M.
中科院分区：
文献类型：
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作者：
Agudelo, Gloria M.;Bedoya, Gabriel;Velasquez, Claudia M.
背景：尽管代谢综合征在青少年中的患病率越来越高，但对其诊断尚无共识。研究方法：通过一项横断面研究，比较不同定义的代谢综合征在青少年中的患病率，评估其一致性，并建议在该人群中应用哪种定义。共对851名10至18岁的青少年进行了评估。采集人体测量（体重、身高、腰围）、生化（血糖、血脂）和血压数据。代谢综合征的患病率由国际糖尿病联合会（IDF）的定义和Cook等人发表的四项研究确定，de Ferranti等人，Agudelo等人，和福特等人。一致性根据kappa指数确定。结果：根据IDF，Cook等，代谢综合征的患病率分别为0.9%，3.8%，4.1%，10.5%和11.4%，福特等人，Agudelo等人，和de Ferranti等人的定义。最常见的成分是高脂血症和低高密度脂蛋白胆固醇，而最不常见的成分是腹部肥胖和高血糖。Cook等人和福特等人的定义之间的一致性最高（kappa=0.92），而de Ferranti等人和IDF定义之间的不一致性最大（kappa=0.14）。结论：代谢综合征及其组分是本研究青少年中存在的疾病。在这一人群中，血脂异常的患病率较高，腹部肥胖和高血糖症的患病率较低，诊断代谢综合征的建议是福特等人使用的建议。
Background: Despite the increasing prevalence of metabolic syndrome in adolescents, there is no consensus for its diagnosis. Methods: A cross-sectional study was conducted to compare the prevalence of metabolic syndrome in adolescents by different definitions, evaluate their concordance, and suggest which definition to apply in this population. A total of 851 adolescents between 10 and 18 years of age were evaluated. Anthropometric (weight, height, waist circumference), biochemical (glucose, lipid profile), and blood pressure data were taken. The prevalence of metabolic syndrome was determined by the definitions of the International Diabetes Federation (IDF) and four published studies by Cook et al., de Ferranti et al., Agudelo et al., and Ford et al. Concordance was determined according to the kappa index. Results: The prevalence of metabolic syndrome was 0.9%, 3.8%, 4.1%, 10.5%, and 11.4%, according to the IDF, Cook et al., Ford et al., Agudelo et al., and de Ferranti et al. definitions, respectively. The most prevalent components were hypertriglyceridemia and low high-density lipoprotein cholesterol, whereas the least prevalent components were abdominal obesity and hyperglycemia. The highest concordance was found between the definitions by Cook et al. and Ford et al. (kappa=0.92), whereas the greatest discordance was between the de Ferranti et al. and IDF definitions (kappa=0.14). Conclusions: Metabolic syndrome and its components were conditions present in the adolescents of this study. In this population, with a high prevalence of dyslipidemia and a lower prevalence of abdominal obesity and hyperglycemia, the recommendation to diagnose metabolic syndrome would be that used by Ford et al.