PYRETHROID TOXICOLOGY - MOUSE INTRA-CEREBRAL STRUCTURE TOXICITY RELATIONSHIPS
PYRETHROID TOXICOLOGY - MOUSE INTRA-CEREBRAL STRUCTURE TOXICITY RELATIONSHIPS
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DOI：
10.1016/0048-3575(82)90082-7
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发表时间：
1982-01-01
影响因子：
4.7
通讯作者：
CASIDA, JE
中科院分区：
文献类型：
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作者：
LAWRENCE, LJ;CASIDA, JE
使用 29 种拟除虫菊酯进行的小鼠脑内 (i.c) 毒性研究证实了早期的小鼠腹腔注射。和大鼠口服和静脉注射3个方面的发现：α-氰基-3-苯氧基苄基酯会引起舞蹈手足徐动、抽搐和流涎，而缺乏α-氰基的化合物则会产生震颤和抽搐；高度立体特异性参与了两种中毒综合征的诱发； (1R,反式) 与(1R,顺式) 灭菊酯和氯菊酯的较大毒性差异并未延伸至乙醚菊酯和氰基苯氧基苄酯。我知道了。研究表明： 大量流涎并不是 α-氰基拟除虫菊酯所独有的；大脑中（1R，反式）灭菊酯的不活动并非由于解毒所致；拟除虫菊酯在大脑中作用最快的是那些对昆虫具有最高击倒活性的物质；与非氰基拟除虫菊酯相比，氰基苯氧基苄酯具有较高的 IC。相对于其协同腹腔内的毒性毒性表明大脑在 2 型中毒综合征中的重要性。
Mouse intracerebral (i.c.) toxicity studies with 29 pyrethroids confirmed earlier mouse i.p. and rat oral and i.v. findings in 3 respects: .alpha.-cyano-3-phenoxybenzyl esters produced choreoathetosis, convulsions and salivation, while compounds lacking the .alpha.-cyano group yielded tremors and convulsions; high stereospecificity was involved in inducing both poisoning syndromes; large toxicity differences for (1R,trans) vs. (1R,cis) resmethrin and permethrin did not extend to ethanomethrin and the cyanophenoxybenzyl esters. I.c. investigations established that: profuse salivation was not unique for pyrethroids with the .alpha.-cyano group; the inactivity of (1R,trans) resmethrin in the brain was not due to detoxification; pyrethroids acting most rapidly in the brain were those with the highest knockdown activity for insects; the cyanophenoxybenzyl esters, in comparsion with the non-cyano pyrethroids, had a high i.c. toxicity relative to their synergized i.p. toxicity indicating the importance of the brain in the type 2 poisoning syndrome.