Synthetic approach for unsaturated precursors for parahydrogen induced polarization of choline and its analogs.
Synthetic approach for unsaturated precursors for parahydrogen induced polarization of choline and its analogs.
复制标题
用于胆碱及其类似物仲氢诱导极化的不饱和前体的合成方法。
DOI：
10.1002/jlcr.3082
复制
发表时间：
2013
影响因子：
1.8
通讯作者：
Chekmenev,EduardY
中科院分区：
文献类型：
--
作者：
Shchepin,RomanV;Chekmenev,EduardY
Reported here are (i) a new synthetic approach for preparation of (ii) a new compound class, of –OH, for example, an –OH group is replaced with acetyl protecting group, protected 1,2‐dehydrocholine analogs and (iii) a new synthetic route for betaine aldehyde. The CC bond of 1,2‐dehydrocholine moiety can be used for molecular addition of parahydrogen producing –OH protected hyperpolarized choline by parahydrogen‐induced polarization (PHIP). The reported synthetic approach allows for incorporation of15N and deuterium labels, which are necessary for preparation of highly polarized PHIP contrast agents. Isotope labeling with15N and/or deuterium was conducted. Hyperpolarized15N‐choline enabled by the reported synthetic approach can be potentially used as an imaging biomarker of cancer similar to choline positron emission tomography tracers.
