THE IMPORTANCE OF LIGHT IN THE ANTI-HIV EFFECT OF HYPERICIN
THE IMPORTANCE OF LIGHT IN THE ANTI-HIV EFFECT OF HYPERICIN
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DOI：
10.1016/0166-3542(93)90006-5
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发表时间：
1993-02-01
影响因子：
7.6
通讯作者：
TOWERS, GHN
中科院分区：
文献类型：
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作者：
HUDSON, JB;HARRIS, L;TOWERS, GHN
研究了金丝桃素的抗 HIV-1 活性对光的需求。测量了反应的金丝桃素浓度依赖性和光剂量依赖性。在金丝桃素导致HIV-1大量失活的情况下，对可见光有严格的要求。只有当金丝桃素的浓度接近细胞毒性水平时，才出现明显的光非依赖性抗病毒作用。这种对抗病毒作用的严格光照要求可以解释其他研究人员报告的一些明显不一致的结果。此外，如果考虑将金丝桃素用于人类，则必须考虑光的重要性。
The requirement for light in the anti-HIV-1 activity of hypericin was investigated. The hypericin concentration-dependence and light dosage-dependence of the reaction were measured. Under conditions in which hypericin caused substantial inactivation of HIV-1, there was a strict requirement for visible light. Only when the concentration of hypericin approached the cytotoxic level was there an apparent light-independent antiviral effect. This strict light-requirement for the antiviral effect could explain some of the apparently discrepant results reported by other workers. Furthermore if hypericin is contemplated for use in humans, the importance of light must be considered.