Multi-functionalized hyaluronic acid nanogels crosslinked with carbon dots as dual receptor-mediated targeting tumor theranostics
Multi-functionalized hyaluronic acid nanogels crosslinked with carbon dots as dual receptor-mediated targeting tumor theranostics
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DOI：
10.1016/j.carbpol.2016.06.109
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发表时间：
2016-11-05
影响因子：
11.2
通讯作者：
Liu, Peng
中科院分区：
文献类型：
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作者：
Jia, Xu;Han, Yu;Liu, Peng
首次将叶酸封端的聚乙二醇修饰透明质酸（FA-PEG-HA）与碳量子点（CD）交联，制备了用于肿瘤诊断和化疗的透明质酸（HA）纳米凝胶。由于整合的CD具有非凡的荧光特性，治疗诊断纳米凝胶可用于对癌细胞的实时和非侵入性定位跟踪。HA可通过静电作用负载阿霉素（DOX），载药量（DLC）为32.5%。该纳米凝胶在弱酸性环境中具有理想的DOX释放，而在中性介质中DOX的释放受到抑制，表现出pH响应性控释行为。细胞毒性和细胞摄取结果清楚地表明，由于其双重受体介导的靶向特性，大多数DOX被释放并积聚在细胞核中并有效地杀死癌细胞。(C)2016爱思唯尔有限公司版权所有
Hyaluronic acid (HA)-based theranostic nanogels were designed for the tumor diagnosis and chemotherapy, by crosslinking the folate-terminated poly(ethylene glycol) modified hyaluronic acid (FA-PEG-HA) with carbon dots (CDs) for the first time. Due to the extraordinary fluorescence property of the integrated CDs, the theranostic nanogels could be used for the real-time and noninvasive location tracking to cancer cells. HA could load Doxorubicin (DOX) via electrostatic interaction with a drug-loading capacity (DLC) of 32.5%. The nanogels possessed an ideal release of DOX in the weak acid environment, while it was restrained in the neutral media, demonstrating the pH-responsive controlled release behavior. The cytotoxicity and cellular uptake results clearly illustrated that most DOX was released and accumulated in the cell nuclei and killed the cancer cells efficaciously, due to their dual receptor-mediated targeting characteristics. (C) 2016 Elsevier Ltd. All rights reserved.