Stimulatory effect of voluntary exercise or fat removal (partial lipectomy) on apoptosis in the skin of UVB light-irradiated mice
Stimulatory effect of voluntary exercise or fat removal (partial lipectomy) on apoptosis in the skin of UVB light-irradiated mice
复制标题
DOI：
10.1073/pnas.0607789103
复制
发表时间：
2006-10-31
影响因子：
11.1
通讯作者：
Conney, Allan H.
中科院分区：
文献类型：
--
作者：
Lu, Yao-Ping;Lou, You-Rong;Conney, Allan H.
早期的研究表明，高膳食脂肪和肥胖与实验动物和人类几个器官部位的癌症风险增加有关。在最近的一项研究中，我们发现，自愿跑轮运动减少体脂肪和抑制紫外线B光（UVB）诱导的表皮癌发生的SKH-1小鼠。在本研究中，我们表明，自愿跑轮运动刺激UVB诱导的表皮细胞凋亡的p53非依赖性机制，自愿运动也刺激UVB诱导的肿瘤荷瘤小鼠的细胞凋亡。运动对未接受UVB治疗的表皮或远离肿瘤的荷瘤小鼠表皮没有影响。此外，我们发现，去除子宫旁脂肪垫（部分脂肪切除术）2周前UVB照射增强UVB诱导的细胞凋亡。我们的研究结果表明，脂肪细胞分泌的物质可以抑制DNA损伤细胞的凋亡，也可能抑制肿瘤细胞的凋亡。我们的研究结果有助于解释为什么运动或各种饮食方案，减少组织脂肪抑制致癌作用。
Earlier studies indicated that high dietary fat and obesity are associated with an increased risk of cancer at several organ sites in experimental animals and in humans. In a recent study we found that voluntary running wheel exercise decreased body fat and inhibited ultraviolet B light (UVB)-induced carcinogenesis in the epidermis of SKH-1 mice. In the present study we demonstrate that voluntary running wheel exercise stimulated UVB-induced apoptosis in the epidermis by a p53-independent mechanism, and voluntary exercise also stimulated apoptosis in UVB-induced tumors in tumor-bearing mice. Exercise had no effect in non-UVB-treated epidermis or in areas of the epidermis away from tumors in tumor-bearing mice. In addition, we found that removal of the parametrial fat pads (partial lipectomy) 2 weeks before UVB irradiation enhanced UVB-induced apoptosis. The results of our studies suggest that fat cells secrete substances that inhibit apoptosis in cells with DNA damage and possibly also in tumors. Our results help explain why exercise or various dietary regimens that decrease tissue fat inhibit carcinogenesis.