LDL-C levels, lipid-lowering treatment and recurrent stroke in minor ischaemic stroke or TIA.
LDL-C levels, lipid-lowering treatment and recurrent stroke in minor ischaemic stroke or TIA.
复制标题
DOI：
10.1136/svn-2021-001317
复制
发表时间：
2022-08
影响因子：
5.9
通讯作者：
中科院分区：
文献类型：
--
作者：
Dyslipidaemia is a major risk factor for ischaemic stroke and transient ischaemic attack (TIA). This study aimed to investigate the association between baseline low-density lipoprotein cholesterol (LDL-C) level, lipid-lowering treatment and short-term risk of new stroke in patients with a minor ischaemic stroke or TIA. We derived data from the Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events trial. Patients with a minor stroke or TIA were categorised by LDL-C level at baseline (<2.6 or ≥2.6 mmol/L (100 mg/dL)) and with or without lipid-lowering treatment after symptom onset. The primary outcome was a new ischaemic stroke at 3 months. The association of baseline LDL-C level, lowering treatment and outcomes were assessed. Among 3027 patients, 2154 (71.2%) patients had an initial LDL-C ≥2.6 mmol/L, of which 1267 (41.9%) received lipid-lowering treatment. Elevated LDL-C level was associated with a higher risk of new ischaemic stroke at 3 months in patients without lipid-lowering treatment (adj.HR=1.35, 95% CI: 1.19 to 1.53), but not in those with lipid-lowering treatment (adj.HR=0.99, 95% CI: 0.82 to 1.19) (p for interaction=0.007). Patients with LDL-C ≥2.6 mmol/L had a numerically higher risk of ischaemic stroke (11.8% vs 8.0%, adj.HR=1.37, 95% CI: 0.96 to 1.96) in those without lipid-lowering treatment. For patients with LDL-C ≥2.6 mmol/L, lipid-lowering treatment was associated with reduced risk of ischaemic stroke at 3 months (7.9% vs 11.8%; adj.HR=0.54, 95% CI: 0.39 to 0.75). Elevated untreated baseline LDL-C level was associated with an increased short-term risk of ischaemic stroke among patients presenting with minor ischaemic stroke or TIA. There was potential benefit of lipid-lowering treatment in minor stroke or TIA patients with LDL-C ≥2.6 mmol/L. NCT00979589.
登录
查看更多内容
影响因子：
120.7
作者：
Lioutas, Vasileios-Arsenios;Ivan, Cristina S.;Seshadri, Sudha
通讯作者：
Seshadri, Sudha
DOI：
10.1016/s0140-6736(20)32332-1
发表时间：
2020-11-21
期刊：
Lancet (London, England)
影响因子：
--
作者：
Gencer B;Marston NA;Im K;Cannon CP;Sever P;Keech A;Braunwald E;Giugliano RP;Sabatine MS
通讯作者：
Sabatine MS
影响因子：
158.5
作者：
Schwartz, G. G.;Steg, P. G.;Ball, Eric
通讯作者：
Ball, Eric
影响因子：
11
作者：
Chung, Jong-Won;Cha, Jihoon;Bang, Oh Young
通讯作者：
Bang, Oh Young
影响因子：
9.9
作者：
Valdes-Marquez, Elsa;Parish, Sarah;Cheng, Yu-Ching
通讯作者：
Cheng, Yu-Ching