THE EFFECT OF DIETARY OILS ON MICROFLORA IN EXPERIMENTAL COLITIS IN MICE
THE EFFECT OF DIETARY OILS ON MICROFLORA IN EXPERIMENTAL COLITIS IN MICE
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发表时间：
2008-09
影响因子：
2
通讯作者：
A. Hekmatdoust;Mirshafiei Abas;Jazayeri Abou Alghasem;M. Eshraghian;M. Feyzabadi;R. Sedaghat;K. Jakobsen
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作者：
A. Hekmatdoust;Mirshafiei Abas;Jazayeri Abou Alghasem;M. Eshraghian;M. Feyzabadi;R. Sedaghat;K. Jakobsen
目的尽管越来越多的证据表明益生菌的益处，但不同的食用油对肠道微生物区系和益生菌的影响尚不清楚。本研究旨在观察不同膳食油类对实验性结肠炎模型肠道菌群的影响。方法给8周龄小鼠喂饲只含脂肪成分的等热量饲料4周。使用的油是鱼油、菜籽油、红花油和含有牛脂的食物。第21天用结肠内注射醋酸诱导大鼠结肠炎。诱导后1周观察大鼠的炎症反应、粪便菌群及血脂变化。结果饮食组炎症程度最高，其次为红花组、菜籽组和鱼油组。饲喂牛脂的小鼠粪便类杆菌数量较多，而粪便双歧杆菌数量较少。此外，鱼油还能显著降低血浆三酰甘油水平。结论多不饱和脂肪酸(PUFAs)可影响肠道菌群，增加益生菌的数量。多不饱和脂肪酸可能被推荐作为益生菌之外的预防和/或维持治疗结肠炎的药物。
OBJECTIVES In spite of growing evidence indicating the benefits of probiotics, the effects of different dietary oils on intestinal microflora and probiotics have not been elucidated. This study aimed to examine the effects of different dietary oils on intestinal microflora in an experimental model of colitis. METHODS Eight-week mice were fed isocaloric diets varying only in fat composition for 4 weeks. The oils used were fish oil, canola oil, safflower oil, and chow diet containing beef tallow. Colitis was induced by intracolonic administration of acetic acid on day 21. The inflammation and fecal microflora and serum lipid profiles were evaluated 1 week after induction. RESULTS Inflammation was highest in the chow diet group followed by safflower, canola, and fish oil fed groups, respectively. The number of fecal bacteroideceae was greater, whereas the number of fecal bifidobacteria was lower in mice fed beef tallow than the other ones. In addition, fish oil reduced the plasma level of triacylglycerole significantly. CONCLUSION Polyunsaturated fatty acids (PUFAs) can affect intestinal microflora increasing the number of probiotics. PUFAs might be recommended in addition to probiotics for the prevention and/or maintenance treatment of colitis.