Phylogenetic analysis of the ATP-binding cassette transporter family in three mosquito species
Phylogenetic analysis of the ATP-binding cassette transporter family in three mosquito species
复制标题
三种蚊子 ATP 结合盒转运蛋白家族的系统发育分析
DOI：
10.1016/j.pestbp.2015.11.006
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发表时间：
2016-09-01
影响因子：
4.7
通讯作者：
Cui, Feng
中科院分区：
文献类型：
--
作者：
Lu, Hong;Xu, Yongyu;Cui, Feng
The ATP-binding cassette (ABC) transporter family functions in the ATP-dependent transportation of various substrates across biological membranes. ABC proteins participate in various biological processes and insecticide resistance in insects, and are divided into eight subfamilies (A-H). Mosquitoes are important vectors of human diseases, but the mechanism by which the ABC transporter family evolves in mosquitoes is unknown. In this study, we classified and compared the ABC transporter families of three mosquitoes, namely, Anopheles gambiae, Aedes aegypti, and Culexpipiens quinquefasciatus. The three mosquitoes have 55, 69, and 70 ABC genes, respectively. The C p. quinquefasciatus had approximately 40% and 65% expansion in the ABCG subfamily, mainly in ABCG1/G4, compared with the two other mosquito species. The ABCB, ABCD, ABCE, and ABCF subfamilies were conserved in the three mosquito species. The C p. quinquefasciatus transcriptomes during development showed that the ABCG and ABCC genes were mainly highly expressed at the egg and pupal stages. The pigment-transport relative brown, white, and scarlet, as well as the ABCF subfamily, were highly expressed at the egg stage. The highly expressed genes in larvae included three ABCA3 genes. The majority of the highly expressed genes in adults were ABCG1/4 genes. These results provided insights into the evolution of the ABC transporter family in mosquitoes. (C) 2015 Elsevier Inc. All rights reserved.
