Placental T2*estimated by magnetic resonance imaging and fetal weight estimated by ultrasound in the prediction of birthweight differences in dichorionic twin pairs
Placental T2*estimated by magnetic resonance imaging and fetal weight estimated by ultrasound in the prediction of birthweight differences in dichorionic twin pairs
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DOI：
10.1016/j.placenta.2019.02.005
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发表时间：
2019-03-01
期刊：
影响因子：
3.8
通讯作者：
Sorensen, Anne
中科院分区：
文献类型：
--
作者：
Poulsen, Sofie Sondrup;Sinding, Marianne;Sorensen, Anne
简介：双胞胎出生体重(BW)的差异与不良结局的风险增加有关。超声估测胎儿体重(EFW)是目前预测双胎出生体重差异的主要方法，但灵敏度较低。因此，需要新的方法。磁共振成像(MRI)估计的胎盘T2*可提供有关胎盘功能的非侵入性信息。本研究旨在探讨胎盘T2*差作为体重差异的新预测因子，并将其与EFW进行比较。方法：对25对妊娠19-38周的双胎进行研究。胎盘T2*由MRI获得，EFW由超声获得。结果：胎盘T2*与体重差值(r=0.80，p<；0.005)与胎盘重量与体重(r=0.64，p<；0.005)呈显著正相关。胎盘T2*差是体重差异的一个很强的独立预测因子(p<；0.001)，并且联合模型的预测效果好于单独一个预测因子(p<；0.0001)。讨论：这项初步研究表明，胎盘T2*差可能是双胞胎间体重差异的预测因子，与胎儿大小无关。这种方法的临床潜力值得在更大的临床研究中进一步研究。
Introduction: Intertwin birthweight (BW) difference is associated with an increased risk of adverse outcome. Ultrasound estimated fetal weight (EFW) is the current method to predict intertwin BW difference, however, the sensitivity is poor. Therefore, new methods are needed. Placental T2* estimated by magnetic resonance imaging (MRI) provides non-invasive information about the placental function. This study aimed to investigate placental T2* difference as a new predictor of BW difference, and to compare it to the EFW.Methods: We included 25 dichorionic twin pairs at 19-38 weeks' gestation. Placental T2* was obtained by MRI and EFW by ultrasound. Correlations between each predictor and BW difference were examined by simple linear regression, and the combined model was analyzed by multiple linear regression and likelihood ratio test.Results: Strong positive correlations were demonstrated between intertwin differences in placental T2* and BW (r = 0.80, p < 0.005), and EFW and BW (r = 0.64, p < 0.005). Placental T2* difference was a strong independent predictor of BW difference (p < 0.001), and the combined model performed better than each predictor alone (p < 0.0001).Discussion: This pilot study demonstrates that placental T2* difference may be a predictor of intertwin BW difference irrespectively of fetal size. The clinical potential of this method deserves further investigation in a larger clinical study