Retrospective detection of asymptomatic monkeypox virus infections among male sexual health clinic attendees in Belgium.
Retrospective detection of asymptomatic monkeypox virus infections among male sexual health clinic attendees in Belgium.
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DOI：
10.1038/s41591-022-02004-w
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发表时间：
2022-11
期刊：
影响因子：
82.9
通讯作者：
Van Esbroeck, Marjan
中科院分区：
文献类型：
--
作者：
De Baetselier, Irith;Van Dijck, Christophe;Kenyon, Chris;Coppens, Jasmine;Michiels, Johan;de Block, Tessa;Smet, Hilde;Coppens, Sandra;Vanroye, Fien;Bugert, Joachim Jakob;Girl, Philipp;Zange, Sabine;Liesenborghs, Laurens;Brosius, Isabel;van Griensven, Johan;Selhorst, Philippe;Florence, Eric;Van den Bossche, Dorien;Arien, Kevin K.;Rezende, Antonio Mauro;Vercauteren, Koen;Van Esbroeck, Marjan
2022 年多国猴痘病毒 (MPXV) 爆发的规模超过了之前的任何一次爆发。目前尚不清楚无症状或未确诊的感染是否加剧了这一流行病。在这项研究中，我们旨在评估 2022 年 5 月到比利时性健康诊所就诊的男性中是否发生未确诊感染。我们使用 MPXV PCR 检测回顾性筛选了 224 份收集的淋病和衣原体检测样本，并从 4 名男性中鉴定出 MPXV-DNA 阳性样本。采样时，一名男子出现疼痛性皮疹，三名男子报告没有任何症状。 21-37 天后进行临床检查，这三名男子没有出现任何临床症状，并且他们报告没有出现任何症状。血清学证实所有三名男子均接触过 MPXV，并且从两例病例中培养出 MPXV。这些发现表明，某些猴痘病例仍未确诊，并表明对报告症状的个人进行检测和隔离可能不足以遏制疫情爆发。人类中未被识别或无症状的猴痘病毒 (MPXV) 感染与具有复制能力的病毒的发现表明，缺乏识别的临床症状可能在病毒传播和 2022 年 MPXV 爆发的规模中发挥作用。
The magnitude of the 2022 multi-country monkeypox virus (MPXV) outbreak has surpassed any preceding outbreak. It is unclear whether asymptomatic or otherwise undiagnosed infections are fuelling this epidemic. In this study, we aimed to assess whether undiagnosed infections occurred among men attending a Belgian sexual health clinic in May 2022. We retrospectively screened 224 samples collected for gonorrhea and chlamydia testing using an MPXV PCR assay and identified MPXV-DNA-positive samples from four men. At the time of sampling, one man had a painful rash, and three men had reported no symptoms. Upon clinical examination 21–37 days later, these three men were free of clinical signs, and they reported not having experienced any symptoms. Serology confirmed MPXV exposure in all three men, and MPXV was cultured from two cases. These findings show that certain cases of monkeypox remain undiagnosed and suggest that testing and quarantining of individuals reporting symptoms may not suffice to contain the outbreak. Findings of unrecognized or asymptomatic monkeypox virus (MPXV) infections with replication-competent virus in humans suggest that a lack of recognized, clinical symptoms could play a role in virus transmission and the magnitude of the 2022 MPXV outbreak.
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