Easy Access to (E)-β-Ocimene
Easy Access to (E)-β-Ocimene
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轻松获得 (E)-β-罗勒烯
作者：
Selma Yildizhan;S. Schulz
β-罗勒烯是自然界中发现的最常见的单萜之一，但纯E-异构体的简单可靠的合成一直缺失。在这里，我们报告了一个简单的程序，涉及一个Grignard耦合的关键步骤，使其合成克规模。双键的构型在起始材料中是固定的。
β-Ocimene is one of the most common monoterpenes found in Nature, but a simple and reliable synthesis of the pure E-isomer has been missing. Here, we report a simple procedure involving a Grignard coupling as the key step that allows its synthesis on gram scales. The configuration of the double bond is fixed in the starting material.