Hydration related changes in tensile response of posterior porcine sclera
Hydration related changes in tensile response of posterior porcine sclera
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DOI：
10.1016/j.jmbbm.2019.103562
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发表时间：
2020-04-01
影响因子：
3.9
通讯作者：
Pachenari, Mohammad
中科院分区：
文献类型：
--
作者：
Hatami-Marbini, Hamed;Pachenari, Mohammad
研究表明，水合作用与角膜等水合组织的生物力学性能之间存在着显著的依赖关系。本研究的主要目的是确定水合作用对巩膜力学性能的影响。从猪眼后部沿上下方向剥离巩膜条，将其干燥后用PBS浸泡至75%、100%、150%、200%水化，分为4个水化组。试验对带材进行了高达1mpa的连续10次加载和卸载。在第10次循环时，试样的响应被用来计算切线模量、最大应变和迟滞作为水化的函数。为了防止力学试验过程中水化变化，实验在油中进行。同时测定了对照组切片后的力学响应。总的来说，随着水分的增加，巩膜条明显软化（p < 0.05）。对照组的应力应变响应介于水化150% ~ 200%之间。实验应力应变数据与R-2 > 0.99呈指数数学关系。本研究表明，水合作用会显著改变巩膜组织的拉伸反应。因此，在力学实验测量中，应仔细控制巩膜标本的水化。
It has been shown that there exists significance dependence between hydration and biomechanical properties of hydrated tissues such as cornea. The primary purpose of this study was to determine hydration effects on mechanical properties of sclera. Sclera' strips, dissected from the posterior part of pig eyes along the superior-inferior direction, were divided into four hydration groups by first drying them and then soaking them in PBS until their hydration reached to 75%, 100%, 150%, and 200%. The strips were subjected to ten consecutive cycles of loading and unloading up to 1 MPa. The response of samples at the tenth cycle was used to compute the tangent modulus, maximum strain, and hysteresis as a function of hydration. The experiments were done in oil in order to prevent hydration changes during the mechanical tests. The mechanical response of strips right after dissection, control group, was also measured. In general, significant softening of scleral strips was found with increasing hydration (p < 0.05). The stress-strain response of control group was between those of samples with hydration 150% and 200%. The experimental stress-strain data were successfully represented numerically with an exponential mathematical relation with R-2 > 0.99. The present study showed that hydration would significantly alter the tensile response of scleral tissue. Thus, the hydration of scleral specimens during mechanical experimental measurements should be carefully controlled.