Gene expression during the life cycle of Drosophila melanogaster
Gene expression during the life cycle of Drosophila melanogaster
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DOI：
10.1126/science.1072152
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发表时间：
2002-09-27
期刊：
影响因子：
56.9
通讯作者：
White, KP
中科院分区：
文献类型：
--
作者：
Arbeitman, MN;Furlong, EEM;White, KP
果蝇的分子遗传学研究在理解发育调控方面取得了深刻的进展。在这里，我们报告的基因表达模式，近三分之一的所有果蝇基因在一个完整的时间过程中的发展。消除眼睛或生殖系组织的突变被用于进一步分析组织特异性基因表达程序。这些研究定义了生命周期中转录程序的主要特征，比较了雄性和雌性的发育，并表明从整个动物中收集的大规模基因表达数据可用于鉴定在特定组织和器官中表达的基因或参与特定生物和生化过程的基因。
Molecular genetic studies of Drosophila melanogaster have led to profound advances in understanding the regulation of development. Here we report gene expression patterns for nearly one-third of all Drosophila genes during a complete time course of development. Mutations that eliminate eye or germline tissue were used to further analyze tissue-specific gene expression programs. These studies de ne major characteristics of the transcriptional programs that underlie the life cycle, compare development in males and females, and show that large-scale gene expression data collected from whole animals can be used to identify genes expressed in particular tissues and organs or genes involved in specific biological and biochemical processes.