Phototriggered Local Anesthesia
Phototriggered Local Anesthesia
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DOI：
10.1021/acs.nanolett.5b03440
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发表时间：
2016-01-01
期刊：
影响因子：
10.8
通讯作者：
Kohane, Daniel S.
中科院分区：
文献类型：
--
作者：
Zhan, Changyou;Wang, Weiping;Kohane, Daniel S.
我们报告了一种光致变色制剂，能够在体内重复和按需麻醉，毒性最小。将可以将近红外（NIR）光转化为热量的金纳米棒（GNRs）附着在脂质体（Lip-GNRs）上，使其脂质双层能够发生光触发相变，从而释放有效载荷。将含有位点1钠通道阻断剂河豚毒素和α（2）-肾上腺素能激动剂右美托咪定（Lip-GNR-TD）的Lip-GNR皮下注射到大鼠足垫中。用808 nm连续波NIR激光照射，在大鼠足垫中产生与辐照度成比例的按需和重复浸润麻醉，毒性最小。实现按需和重复局部麻醉的能力在疼痛管理中可能非常有益。
We report a phototriggerable formulation enabling in vivo repeated and on-demand anesthesia with minimal toxicity. Gold nanorods (GNRs) that can convert near-infrared (NIR) light into heat were attached to liposomes (Lip-GNRs), enabling light-triggered phase transition of their lipid bilayers with a consequent release of payload. Lip-GNRs containing the site 1 sodium channel blocker tetrodotoxin and the alpha(2)-adrenergic agonist dexmedetomidine (Lip-GNR-TD) were injected subcutaneously in the rat footpad. Irradiation with an 808 nm continuous wave NIR laser produced on-demand and repeated infiltration anesthesia in the rat footpad in proportion to the irradiance, with minimal toxicity. The ability to achieve on-demand and repeated local anesthesia could be very beneficial in the management of pain.