DNA gyrase gyrA mutations in ciprofloxacin-resistant strains of Staphylococcus aureus: close similarity with quinolone resistance mutations in Escherichia coli
DNA gyrase gyrA mutations in ciprofloxacin-resistant strains of Staphylococcus aureus: close similarity with quinolone resistance mutations in Escherichia coli
复制标题
金黄色葡萄球菌耐环丙沙星菌株中的 DNA 旋转酶 gyrA 突变：与大肠杆菌中的喹诺酮耐药突变非常相似
DOI：
10.1128/jb.172.12.7260-7262.1990
复制
发表时间：
1990
影响因子：
3.2
通讯作者：
'. Fisher
中科院分区：
文献类型：
--
作者：
S. Sreedharan;'. B. Jensen;L. Peterson;L. Mark;'. Fisher
从3株临床分离的环丙沙星耐药金黄色葡萄球菌中分离到的gyrA基因携带有前处理敏感株所没有的84密码子(丝氨酸-亮氨酸)和/或85密码子(丝氨酸-脯氨酸)突变。这些替换发生在旋转酶A蛋白的一个区域，在该区域中，大肠杆菌中丝氨酸83-亮氨酸和丙氨酸84-脯氨酸的直接相似突变导致了对喹诺酮类药物的耐药性。因此，DNA旋转酶A亚单位突变与金黄色葡萄球菌对环丙沙星的耐药性有关。
The gyrA genes isolated from three ciprofloxacin-resistant clinical isolates of Staphylococcus aureus carried codon 84 (serine----leucine) and/or codon 85 (serine----proline) mutations that were absent in pretreatment susceptible strains. These substitutions occur in a region of the gyrase A protein wherein directly analogous mutations of serine 83----leucine and alanine 84----proline in Escherichia coli confer quinolone resistance. Thus, DNA gyrase A subunit mutations are implicated in resistance to ciprofloxacin in S. aureus.