Clinical evaluation of serum tissue inhibitor of metalloproteinases‐1 levels in patients with liver diseases
Clinical evaluation of serum tissue inhibitor of metalloproteinases‐1 levels in patients with liver diseases
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肝病患者血清组织金属蛋白酶抑制剂α1水平的临床评价
DOI：
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发表时间：
1993
影响因子：
4.1
通讯作者：
T. Hayakawa
中科院分区：
文献类型：
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作者：
D. Muzzillo;M. Imoto;Y. Fukuda;Y. Koyama;S. Saga;Y. Nagai;T. Hayakawa
通过一步夹心酶免疫测定法测定了 268 名肝病患者的金属蛋白酶组织抑制剂 1 (TIMP-1) 的血清水平。在急性肝炎、慢性活动性肝炎（CAH）、肝硬化（LC）和肝细胞癌（HCC）病例中，TIMP-1的水平高于对照组。金属蛋白酶-1 组织抑制剂水平与 III 型前胶原肽和 IV 型胶原相关，表明 TIMP-1 作为肝纤维化的有用标志物。 TIMP-1 水平还与天冬氨酸转氨酶和丙氨酸转氨酶水平相关，并且在急性肝炎中表现出最高水平。因此，TIMP-1也可能反映肝脏炎症。 HCC患者血清甲胎蛋白与TIMP-1水平呈显着正相关。 LC和HCC之间TIMP-1的截止水平设定为440 ng/mL，具有低敏感性和高特异性。这些结果表明 TIMP-1 作为肿瘤标志物在甲胎蛋白水平不升高的 HCC 病例中是有用的。
Serum levels of the tissue inhibitor of metalloproteinases‐1 (TIMP‐1) were measured in 268 patients with liver diseases by means of a one‐step sandwich enzyme immunoassay. In the cases of acute hepatitis, chronic active hepatitis (CAH), liver cirrhosis (LC) and hepatocellular carcinoma (HCC), the levels of TIMP‐1 were higher than those of the control group. Tissue inhibitor of metalloproteinases‐1 levels correlated with type III procollagen peptide and with type IV collagen, indicating TIMP‐1 as a useful marker for hepatic fibrosis. Levels of TIMP‐1 also correlated with aspartate aminotransserase and alanine aminotransferase levels and showed the highest levels in acute hepatitis. Thus, TIMP‐1 might also reflect hepatic inflammation. Serum levels of α‐fetoprotein and TIMP‐1 had a significant positive correlation in patients with HCC. A cut‐off level of TIMP‐1 between LC and HCC was set at 440 ng/mL, having a low sensitivity and a high specificity. These results suggest the usefulness of TIMP‐1 as a tumour marker in cases of HCC where α‐fetoprotein levels are not elevated.
影响因子：
11.2
作者：
Y. DeClerck;N. Perez;Hiroyuki Shimada;T. Boone;K. Langley;Shirley M. Taylor
通讯作者：
Y. DeClerck;N. Perez;Hiroyuki Shimada;T. Boone;K. Langley;Shirley M. Taylor