Novel U-bent fiber optic probe for localized surface plasmon resonance based biosensor
Novel U-bent fiber optic probe for localized surface plasmon resonance based biosensor
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DOI：
10.1016/j.bios.2009.02.007
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发表时间：
2009-05-15
影响因子：
12.6
通讯作者：
Mukherji, Soumyo
中科院分区：
文献类型：
--
作者：
Sai, V. V. R.;Kundu, Tapanendu;Mukherji, Soumyo
本研究的目的是开发一种基于光吸收的生物传感器，适用于资源贫乏地区的大规模使用。描述了一种用于借助于金纳米颗粒（GNP）的光吸收特性来灵敏地测量折射率（RI）的传感器，该传感器耦合到U形弯曲光纤探针形式的高效光学换能器。通过一个简单的程序，U形弯曲探针的制作。发现由于纤维结合的GNP的局部表面等离子体共振（LSPR）的吸光度与1.33和1.35之间的折射率变化呈线性。直径为200 μ m、弯曲半径为0.75 mm的U形弯曲探针在540 nm处的灵敏度为35 Δ A/RIU。传感器探头的分辨率为3.8 x 10（-5）RIU。使用这些探针的IgG-抗IgG作为生物受体-分析物对的帮助下，证明了无标记的生物传感。(C)2009 Elsevier B. V.保留所有权利。
The aim of this study is to develop an optical absorbance based biosensor suitable for wide scale use in resource-poor locales. A sensor for sensitive measurement of refractive index (RI) with the help of optical absorbance properties of gold nanoparticles (GNP) coupled to an efficient optical transducer in the form of a U-bent fiber optic probe is described. A U-bent probe was fabricated by a simple procedure. The absorbance due to the localized surface plasmon resonance (LSPR) of fiber-bound GNP was found to be linear to refractive index changes between 1.33 and 1.35. A U-bent probe of 200 mu m diameter with a bend radius of 0.75 mm gave rise to a sensitivity of 35 Delta A/RIU at 540 nm. The resolution of the sensor probe was 3.8 x 10(-5) RIU. Label-free biosensing was demonstrated using these probes with the help of IgG-anti IgG as bioreceptor-analyte pair. (C) 2009 Elsevier B.V. All rights reserved.