Novel Flavones from the Root of Phytolacca acinosa Roxb.
Novel Flavones from the Root of Phytolacca acinosa Roxb.
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DOI：
10.1002/cbdv.201700361
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发表时间：
2017-12
影响因子：
2.9
通讯作者：
Xiao-Pan Ma;Wen-Fang Zhang;Ping Yi;Jun-Jie Lan;Bin Xia;Sai Jiang;Hua-yong Lou;W. Pan
中科院分区：
文献类型：
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作者：
Xiao-Pan Ma;Wen-Fang Zhang;Ping Yi;Jun-Jie Lan;Bin Xia;Sai Jiang;Hua-yong Lou;W. Pan
从商陆（Phytolacca acinosa Rox B）根的乙醇提取物中分离得到两个新黄酮类化合物：6，7-亚甲二氧基-4-羟基-7-雌酮（1）、旋叶素（cochliophilin）B（2），以及两个已知黄酮类化合物：旋叶素A（3）和6-甲氧基-7-羟基黄酮（4）。化合物1是具有一个δ-内酯单元的黄烷醇骨架，其在自然界中相当罕见。新化合物的结构通过大量的光谱（IR，MS，1D-和2D-NMR）分析确定，1的绝对构型通过比较实验和计算的电子圆二色光谱确定。通过与文献数据的比较，确定了已知化合物的结构。化合物2和化合物4对BEL-7402细胞有一定的抑制活性，IC 50值分别为28.22和39.16 μmol/L。
Two new flavones, 6,7‐methylenedioxy‐4‐hydroxypeltogynan‐7′‐one (1), cochliophilin B (2), as well as two known ones, cochliophilin A (3) and 6‐methoxy‐7‐hydroxy flavone (4), were isolated from the ethanol extract of the root of Phytolacca acinosa Roxb. Compound 1 is a flavanol framework with one δ‐lactone unit, which is rather rare in nature. The structures of the new compounds were determined on the basis of extensive spectroscopic (IR, MS, 1D‐ and 2D‐NMR) analyses, the absolute configuration of 1 was established by comparing experimental and calculated electronic circular dichroism spectra. The structures of known compounds were fixed by comparison with literatures data. Compounds 2 and 4 showed modest inhibitory activities against BEL‐7402 cell line, with IC50 values of 28.22 and 39.16 μmol/L, respectively.