Primary ovary choriocarcinoma: individual DNA polymorphic analysis as a strategy to confirm diagnosis and treatment.
Primary ovary choriocarcinoma: individual DNA polymorphic analysis as a strategy to confirm diagnosis and treatment.
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DOI：
10.4081/rt.2013.e24
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发表时间：
2013-04-15
期刊：
影响因子：
0.9
通讯作者：
Diz Mdel P
中科院分区：
文献类型：
--
作者：
Exman P;Takahashi TK;Gattás GF;Cantagalli VD;Anton C;Nalesso F;Diz Mdel P
卵巢原发性绒毛膜癌很少见。此外，这种肿瘤可能源自妊娠组织或卵巢的纯生殖细胞，后者导致非妊娠绒毛膜癌。虽然两种肿瘤类型的临床特征和组织学相同，但有效治疗必须区分这些肿瘤。区分这些肿瘤类型的一种策略是检测父本 DNA 的存在。因此，在本病例中，通过DNA分析证实患有非妊娠起源的卵巢原发性绒毛膜癌的患者。患者随后对化疗表现出良好的反应，并在手术后达到完全缓解。手术标本的病理分析进一步证实不存在肿瘤。
Primary choriocarcinoma of the ovary is rare. Furthermore, this tumor can arise from gestational tissue or pure germ cells of the ovary, with the latter resulting in non-gestational choriocarcinoma. While the clinical characteristics and histology of both tumor types are identical, differentiation of these tumors is necessary for effective treatment. One strategy for the differentiation of these tumors types is to assay for the presence of paternal DNA. Accordingly, in the present case, a patient with primary choriocarcinoma of the ovary with a non-gestational origin was confirmed by DNA analysis. The patient subsequently exhibited an excellent response to chemotherapy, and following surgery, achieved complete remission. A pathological analysis of surgical specimens further confirmed the absence of tumor.