Neurobiology of cholecystokinin.
Neurobiology of cholecystokinin.
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发表时间：
1994
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通讯作者：
Moran Th;Schwartz Gj
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作者：
Moran Th;Schwartz Gj
摘要缩胆囊素（CCK）广泛分布于哺乳动物脑内，是一种神经递质和神经调质。CCK与其他神经递质共定位于多种大脑部位。CCK受体亚型已被确定，其分布在大脑和周边。外源性CCK根据给药部位发挥多种作用，其中许多作用模拟内源性肽的作用。对CCK在大脑和行为中的潜在作用的理解进展集中在四个主要领域：CCK/多巴胺相互作用，焦虑和恐慌状态中的CCK，阿片类伤害感受中的CCK和饱腹感中的CCK。CCK在调节其他神经递质系统的活性或影响行为方面的作用可能是未来治疗干预的基础。
Abstract The peptide cholecystokinin (CCK) is widely distributed throughout the mammalian brain where it functions as a neurotransmitter and neuromodulator. CCK is colocalized with other neurotransmitters at a variety of brain sites. CCK receptor subtypes have been identified and their distributions mapped in the brain and the periphery. Exogenous CCK exerts a variety of effects depending on the site of administration, and many of these effects mimic actions of the endogenous peptide. Progress in understanding of the potential role of CCK in brain and behavior has focused on four main areas: CCK/dopamine interactions, CCK in anxiety and panic states, CCK in opioid nociception, and CCK in satiety. CCK's actions in modulating the activity of other neurotransmitters systems or in affecting behavior may serve as the bases for future therapeutic interventions.