Ancient genomes from Iceland reveal the making of a human population
Ancient genomes from Iceland reveal the making of a human population
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DOI：
10.1126/science.aar2625
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发表时间：
2018-06-01
期刊：
影响因子：
56.9
通讯作者：
Helgason, Agnar
中科院分区：
文献类型：
--
作者：
Ebenesersdottir, S. Sunna;Sandoval-Velasco, Marcela;Helgason, Agnar
直接研究人类种群的建立及其随后的进化历史的机会是罕见的。使用27个古代冰岛人的基因组序列数据，我们证明他们是挪威人，盖尔人和混合个体的组合。我们进一步表明，这些古老的冰岛人是显着更类似于他们的源人口在斯堪的纳维亚半岛和英国-爱尔兰群岛比当代冰岛人，谁已经形成了1100年的广泛的遗传漂变。最后，我们报告的证据不平等的贡献从古代创始人到当代冰岛基因库。这些结果提供了详细的见解，使人类人口已被证明是非常有用的发现基因型-表型协会。
Opportunities to directly study the founding of a human population and its subsequent evolutionary history are rare. Using genome sequence data from 27 ancient Icelanders, we demonstrate that they are a combination of Norse, Gaelic, and admixed individuals. We further show that these ancient Icelanders are markedly more similar to their source populations in Scandinavia and the British-Irish Isles than to contemporary Icelanders, who have been shaped by 1100 years of extensive genetic drift. Finally, we report evidence of unequal contributions from the ancient founders to the contemporary Icelandic gene pool. These results provide detailed insights into the making of a human population that has proven extraordinarily useful for the discovery of genotype-phenotype associations.