Bioactive SrO-SiO2 glass with well-ordered mesopores: characterization, physiochemistry and biological properties.
Bioactive SrO-SiO2 glass with well-ordered mesopores: characterization, physiochemistry and biological properties.
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DOI：
10.1016/j.actbio.2010.12.018
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发表时间：
2011-04
影响因子：
9.7
通讯作者：
Chengtie Wu;W. Fan;M. Gelinsky;Yin Xiao;P. Simon;R. Schulze;T. Doert;Yongxiang Luo;G. Cuniberti
中科院分区：
文献类型：
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作者：
Chengtie Wu;W. Fan;M. Gelinsky;Yin Xiao;P. Simon;R. Schulze;T. Doert;Yongxiang Luo;G. Cuniberti
对于适合骨修复的生物材料来说，理想情况下它应该具有生物活性并具有可控药物输送的能力；因此，介孔SiO2玻璃因其高载药能力和良好的生物相容性而被提出作为一类新型骨再生材料。然而，它的生物活性和可控药物输送特性确实较差。在这项研究中，我们将锶（Sr）掺入介孔SiO2中，试图开发一种具有生物活性的介孔SrO-SiO2(Sr-Si)玻璃，该玻璃能够以受控的速率输送Sr2+离子以及药物，从而生产出更适合骨修复的材料。研究了Sr2+对介孔Sr-Si玻璃结构、物理化学、药物递送和生物学性能的影响。研究发现所制备的介孔Sr-Si玻璃具有优异的生物活性Sr2+离子和地塞米松的释放特性，并且Sr2+的掺入改善了结构性能，例如介孔尺寸、孔体积和比表面积，以及溶解速率和蛋白质吸附。介孔Sr-Si玻璃没有细胞毒性作用，其释放的Sr2+和SiO44-离子增强了人骨间充质干细胞中的碱性磷酸酶活性（成骨细胞分化的标志物）。介孔Sr-Si玻璃可以制备成多孔支架，从而表现出更持久的药物释放。这项研究表明，将 Sr2+ 掺入介孔 SiO2 玻璃中可产生一种具有更佳药物输送特性以及改善的生物活性的材料，使其成为骨修复应用的优异材料。
For a biomaterial to be considered suitable for bone repair it should ideally be both bioactive and have a capacity for controllable drug delivery; as such, mesoporous SiO2glass has been proposed as a new class of bone regeneration material by virtue of its high drug-loading ability and generally good biocompatibility. It does, however, have less than optimum bioactivity and controllable drug delivery properties. In this study, we incorporated strontium (Sr) into mesoporous SiO2in an effort to develop a bioactive mesoporous SrO–SiO2(Sr–Si) glass with the capacity to deliver Sr2+ions, as well as a drug, at a controlled rate, thereby producing a material better suited for bone repair. The effects of Sr2+on the structure, physiochemistry, drug delivery and biological properties of mesoporous Sr–Si glass were investigated. The prepared mesoporous Sr–Si glass was found to have an excellent release profile of bioactive Sr2+ions and dexamethasone, and the incorporation of Sr2+improved structural properties, such as mesopore size, pore volume and specific surface area, as well as rate of dissolution and protein adsorption. The mesoporous Sr–Si glass had no cytotoxic effects and its release of Sr2+and SiO44−ions enhanced alkaline phosphatase activity – a marker of osteogenic cell differentiation – in human bone mesenchymal stem cells. Mesoporous Sr–Si glasses can be prepared to porous scaffolds which show a more sustained drug release. This study suggests that incorporating Sr2+into mesoporous SiO2glass produces a material with a more optimal drug delivery profile coupled with improved bioactivity, making it an excellent material for bone repair applications.