Circadian rhythms in liver metabolism and disease.
Circadian rhythms in liver metabolism and disease.
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DOI：
10.1016/j.apsb.2015.01.003
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Chiang JY
中科院分区：
文献类型：
--
作者：
Ferrell JM;Chiang JY
越来越多的研究证据表明，昼夜节律紊乱对人类健康有重大的负面影响。轮班工作、慢性时差反应和睡眠障碍会增加代谢综合征的发病率，从而导致肥胖、2型糖尿病和血脂异常。在这里，我们就肝脏代谢和疾病的关系作一综述。轮班工作、慢性时差反应和睡眠障碍会增加代谢综合征的发病率，从而导致肥胖、2型糖尿病和血脂异常。在这里，我们就肝脏代谢和疾病的关系作一综述。
Mounting research evidence demonstrates a significant negative impact of circadian disruption on human health. Shift work, chronic jet lag and sleep disturbances are associated with increased incidence of metabolic syndrome, and consequently result in obesity, type 2 diabetes and dyslipidemia. Here, these associations are reviewed with respect to liver metabolism and disease. Shift work, chronic jet lag, and sleep disturbances are associated with increased incidence of metabolic syndrome, and consequently result in obesity, Type 2 diabetes and dyslipidemia. Here, these associations are reviewed with respect to liver metabolism and disease.