FORMATION OF DIRECTLY MUTAGENIC ALPHA-HYDROXY-N-NITROSOPIPERIDINE PHOSPHATE ESTER BY NEAR-ULTRAVIOLET IRRADIATION OF N-NITROSOPIPERIDINE IN PHOSPHATE BUFFER
FORMATION OF DIRECTLY MUTAGENIC ALPHA-HYDROXY-N-NITROSOPIPERIDINE PHOSPHATE ESTER BY NEAR-ULTRAVIOLET IRRADIATION OF N-NITROSOPIPERIDINE IN PHOSPHATE BUFFER
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DOI：
10.1016/0006-291x(89)90792-4
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发表时间：
1989-08-15
影响因子：
3.1
通讯作者：
HAYATSU, H
中科院分区：
文献类型：
--
作者：
ARIMOTO, S;SHIMADA, H;HAYATSU, H
以前，我们发现，直接作用的诱变剂可以形成从N-亚硝基二烷基胺暴露于近紫外光在磷酸盐的存在下。我们现在已经分离出由N-亚硝基哌啶和无机磷酸盐形成的诱变光产物，并鉴定其结构为α-哌啶的磷酸酯。羟基-N-亚硝基哌啶。该反应代表了一种新的、非酶促的致突变N-亚硝基二烷基胺活化。
Previously we found that direct-acting mutagens can be formed from N-nitrosodialkylamines on exposure to near-ultraviolet light in the presence of phosphates. We have now isolated the mutagenic photoproduct formed from N-nitrosopiperidine and inorganic phosphate and identified its structure as the phosphate ester of .alpha.-hydroxy-N-nitrosopiperidine. This reaction represents a new, non-enzymatic activation of promutagenic N-nitrosodialkylamines.