Antigenic and genetic diversity among swine influenza A H1N1 and H1N2 viruses in Europe
Antigenic and genetic diversity among swine influenza A H1N1 and H1N2 viruses in Europe
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DOI：
10.1099/0022-1317-83-4-735
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发表时间：
2002-04-01
影响因子：
3.8
通讯作者：
Hay, A
中科院分区：
文献类型：
--
作者：
Marozin, S;Gregory, V;Hay, A
甲型流感病毒的三种亚型H1N1、H1 N2和H3 N2在欧洲的猪中共同进化。自1997年以来在法国和意大利从猪身上分离出的H1 N2病毒与1994年在英国出现的H1 N2病毒密切相关。特别是，这些病毒的神经氨酸酶（NAs）的密切关系，以NA的英国以前的H3 N2猪病毒表明，他们没有获得NA从H3 N2猪病毒在欧洲大陆传播。此外，H1 N2病毒之间的抗原和遗传异质性似乎部分是由于来自英国的病毒的多次引入。另一方面，内部基因序列的比较表明，H1 N2病毒与共同传播的H1N1和/或H3 N2亚型之间存在遗传交换。早期（1997-1998年）H1 N2分离株的大多数基因与当代法国H1N1分离株的基因更密切相关，而后来（1999-2000年）分离株的基因，包括一些H1 N2病毒的HA，与1999年在法国出现的独特H1N1抗原变体的基因密切相关。相反，1999年在法国分离的H3 N2病毒在抗原性和遗传学上与当代人类A/Sydney/5/97样病毒密切相关。这些研究揭示了猪和人类群体中H1N1病毒的遗传和抗原漂移之间有趣的相似之处，并提供了遗传重配对猪流感病毒的抗原和遗传多样性的贡献以及内部基因互补在动物流行毒株进化中的重要性的进一步例子。
Three subtypes of influenza A viruses, H1N1, H1N2 and H3N2, co-evolve in pigs in Europe. H1N2 viruses isolated from pigs in France and Italy since 1997 were closely related to the H1N2 viruses which emerged in the UK in 1994. In particular, the close relationship of the neuraminidases (NAs) of these viruses to the NA of a previous UK H3N2 swine virus indicated that they had not acquired the NA from H3N2 swine viruses circulating in continental Europe. Moreover, antigenic and genetic heterogeneity among the H1N2 viruses appeared to be due in part to multiple introductions of viruses from the UK. On the other hand, comparisons of internal gene sequences indicated genetic exchange between the H1N2 viruses and co-circulating H1N1 and/or H3N2 subtypes. Most genes of the earlier (1997-1998) H1N2 isolates were more closely related to those of a contemporary French H1N1 isolate, whereas the genes of later (1999-2000) isolates, including the HAs of some H1N2 viruses, were closely related to those of a distinct H1N1 antigenic variant which emerged in France in 1999. In contrast, an H3N2 virus isolated in France in 1999 was closely related antigenically and genetically to contemporary human A/Sydney/5/97-like viruses. These studies reveal interesting parallels between genetic and antigenic drift of H1N1 viruses in pig and human populations, and provide further examples of the contribution of genetic reassortment to the antigenic and genetic diversity of swine influenza viruses and the importance of the complement of internal genes in the evolution of epizootic strains.