Possible implications of non-linear radiobiological effects for the estimation of radiation risk at low doses.
Possible implications of non-linear radiobiological effects for the estimation of radiation risk at low doses.
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非线性放射生物学效应对低剂量辐射风险估计的可能影响。
DOI：
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发表时间：
2002
影响因子：
1
通讯作者：
W. Heidenreich
中科院分区：
文献类型：
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作者：
V. Prokić;P. Jacob;W. Heidenreich
研究了低LET辐射在低剂量下诱导癌症的可能影响。低剂量超敏反应和适应性反应被确定为候选，它们可能对急性暴露产生非线性剂量效应曲线，而适应性反应可能影响长期暴露。本文研究了急性暴露。几份关于哺乳动物细胞系研究的放射生物学报告表明，在低剂量辐射生存反应中存在一个超敏感区，随后辐射耐药性增加。两步克隆扩增（TSCE）模型适用于癌变过程，即急性辐射后的细胞杀伤在一段时间内诱导克隆扩增增加，从而发挥辐射的促进作用。作为第一步，拟合辐射效应研究基金会（RERF）关于肺癌发病率的数据，以研究这种模型如何影响低剂量下癌症风险的评估。
Possible implications of the effects of low LET radiation on the induction of cancer at low doses are studied. Low dose hypersensitivity and adaptive response were identified as candidates which may give a non-linear dose effect curve for acute exposures, whereas adaptive response may influence protracted exposures. In this paper acute exposures are studied. Several radiobiological reports on studies with mammalian cell lines have indicated the presence of a hypersensitive region in the radiation survival response at low doses followed by an increase in radioresistance. The two step clonal expansion (TSCE) model for the process of carcinogenesis was adapted in such a way that cell killing after acute radiation induces increased clonal expansion for some time and thus gives a promoting effect of radiation. As a first step, the Radiation Effects Research Foundation (RERF) data on the lung cancer incidence are fitted to study how such a model would influence the assessment of the cancer risk at low doses.