Depressive state relates to female oxidative DNA damage via neutrophil activation
Depressive state relates to female oxidative DNA damage via neutrophil activation
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DOI：
10.1016/j.bbrc.2003.10.105
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发表时间：
2003-11-28
影响因子：
3.1
通讯作者：
Kasai, H
中科院分区：
文献类型：
--
作者：
Irie, M;Asami, S;Kasai, H
本研究利用人类白细胞中与癌症相关的氧化DNA损伤的生物标志物8-羟基脱氧鸟苷（8-OH-dG），研究了心理压力（尤其是抑郁）导致的癌症风险及其潜在机制。我们对156名工人进行了一项横断面研究，研究了8-OH-dG水平与一般健康问卷（GHQ）和流行病学研究中心抑郁量表（CES-D）得分的关系。我们还研究了8-OH-dG合成可能与中性粒细胞的应激相关增加有关的可能性，中性粒细胞在心理应激反应中产生超氧化物。女性重度抑郁GHQ评分与8-OH-dG水平呈显著正相关，男性重度抑郁CES-D评分与8-OH-dG水平呈显著负相关。女性中性粒细胞百分比与8-OH-dG水平呈正相关。女性因DNA氧化损伤导致的心理抑郁与癌症风险相关，可能通过中性粒细胞激活。(C) 2003 Elsevier Inc.版权所有。
This study investigated cancer risk due to psychological stress, particularly depression, and its underlying mechanism, using a biomarker of cancer-related oxidative DNA damage, 8-hydroxydeoxyguanosine (8-OH-dG), in human leukocytes. We performed a cross-sectional study of 156 workers in which we examined the relationships of the 8-OH-dG levels to the scores of the General Health Questionnaire (GHQ) and the Center for Epidemiologic Studies Depression scale (CES-D). We also examined the possibility that 8-OH-dG synthesis might be associated with a stress-related increase in neutrophils, which have been reported to produce superoxide in response to psychological stress. The Severe depression scores of the GHQ in females were strongly and positively associated with the 8-OH-dG levels, whereas the CES-D scores in males were negatively associated. There was a positive correlation between the percentage of neutrophils and the 8-OH-dG levels in females. Psychological depression was related to cancer risk due to oxidative DNA damage in females, possibly via neutrophil activation. (C) 2003 Elsevier Inc. All rights reserved.