The biological significance of tobacco-specific N-nitrosamines: Smoking and adenocarcinoma of the lung
The biological significance of tobacco-specific N-nitrosamines: Smoking and adenocarcinoma of the lung
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DOI：
10.3109/10408449609017931
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发表时间：
1996-01-01
影响因子：
5.9
通讯作者：
Hecht, SS
中科院分区：
文献类型：
--
作者：
Hoffmann, D;Rivenson, A;Hecht, SS
在美国，在吸烟者中，肺腺癌的发病率比肺鳞状细胞癌的发病率急剧上升。自1950年以来，所有销售的香烟中有过滤嘴的百分比从0.56%增加到1990年的92%和1990年的97%。过滤嘴香烟的烟草比过去几十年制造的无过滤嘴香烟的烟草含有更丰富的硝酸盐。由于尼古丁含量较低的香烟吸烟者往往比普通香烟吸烟者吸烟更强烈，吸入的烟雾更深，因此外周肺暴露于更大量的氮氧化物、亚硝化化合物和肺特异性烟雾致癌物。我们的工作假设是，更强烈的吸烟、更深的烟雾吸入以及更高的器官特异性肺致癌物NNK向外周肺的烟雾递送是吸烟者患肺腺癌风险增加的主要因素。支持这一概念的生物测定数据和生化研究进行了讨论。
In the U.S., there has been a steeper rise of the incidence of lung adenocarcinoma than of squamous cell carcinoma of the lung among cigarette smokers. Since 1950, the percentage of all cigarettes sold that had filter tips increased from 0.56 to 92% in 1990 and to 97% in 1990. The tobacco of the filter cigarettes is richer in nitrate than that of the nonfilter cigarettes manufactured in past decades. Because the smoker of cigarettes with lower nicotine yield tends to smoke more intensely and to inhale the smoke more deeply than the smoker of plain cigarettes, the peripheral lung is exposed to higher amounts of nitrogen oxides, nitrosated compounds, and lung-specific smoke carcinogens. It is our working hypothesis that more intense smoking, deeper inhalation of the smoke, and higher smoke delivery of the organ-specific lung carcinogen NNK to the peripheral lung are major contributors to the increased risk of cigarette smokers for lung adenocarcinoma. Bioassay data and biochemical studies in support of this concept are discussed.