Life-long endurance exercise in humans: Circulating levels of inflammatory markers and leg muscle size
Life-long endurance exercise in humans: Circulating levels of inflammatory markers and leg muscle size
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DOI：
10.1016/j.mad.2013.11.004
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发表时间：
2013-11-01
影响因子：
5.3
通讯作者：
Kjaer, M.
中科院分区：
文献类型：
--
作者：
Mikkelsen, U. R.;Couppe, C.;Kjaer, M.
人类衰老与骨骼肌的损失和循环炎症标志物的增加有关。目前尚不清楚耐力训练（Tr）是否可以防止这些变化。因此，我们研究了15名老年训练（0-Tr）的健康男性，并作为比较，12名老年未训练（O-Un），10名Young-Tr（Y-Tr）和12名Young-Un（Y-Un）。测量股四头肌大小、VO 2峰值、CRP、IL-6、TNF-α及其受体、suPAR、血脂、白细胞和葡萄糖稳态。Tr与胰岛素谱改善（p < 0.05）、白细胞减少（p < 0.05）和甘油三酯水平降低（p < 0.05）相关，与年龄无关。年龄与较差的血糖控制相关（p < 0.05），与训练无关。体力活动可抵消腰围、V02峰值、胆固醇、LDL、腿部肌肉尺寸、CRP和IL-6的增龄性变化（p < 0.05）。观察到suPAR随年龄增加而显著增加（p < 0.05）。最重要的是，与年龄匹配的未经训练的同龄人相比，终身耐力运动与较低的炎症标志物CRP和IL-6水平（p <0.05）以及较大的大腿肌肉面积（p < 0.05）相关。在有限的一组个体中的这些发现表明，定期的身体耐力活动可能在减少全身炎症的一些标志物方面发挥作用，即使在正常范围内，并且随着年龄的增长保持肌肉质量。(C)2013爱思唯尔爱尔兰有限公司版权所有。
Human aging is associated with a loss of skeletal muscle and an increase in circulating inflammatory markers. It is unknown whether endurance training (Tr) can prevent these changes. Therefore we studied 15 old trained (0-Tr) healthy males and, for comparison, 12 old untrained (O-Un), 10 Young-Tr (Y-Tr) and 12 Young-Un (Y-Un). Quadriceps size, VO2 peak, CRP, IL-6, TNF-alpha and its receptors, suPAR, lipid profile, leucocytes and glucose homeostasis were measured. Tr was associated with an improved insulin profile (p < 0.05), and lower leucocyte (p < 0.05) and triglyceride levels (p < 0.05), independent of age. Aging was associated with poorer glucose control (p < 0.05), independent of training. The agerelated changes in waist circumference, V02 peak, cholesterol, LDL, leg muscle size, CRP and 1L-6 were counteracted by physical activity (p < 0.05). A significant increase in suPAR with age was observed (p < 0.05). Most importantly, life-long endurance exercise was associated with a lower level of the inflammatory markers CRP and IL-6 (p < 0.05), and with a greater thigh muscle area (p < 0.05), compared to age-matched untrained counterparts. These findings in a limited group of individuals suggest that regular physical endurance activity may play a role in reducing some markers of systemic inflammation, even within the normal range, and in maintaining muscle mass with aging. (C) 2013 Elsevier Ireland Ltd. All rights reserved.