AMIDE-BASED PROTECTING/RADICAL TRANSLOCATING (PRT) GROUPS - GENERATION OF RADICALS ADJACENT TO CARBONYLS BY 1,5-HYDROGEN TRANSFER-REACTIONS OF O-IODOANILIDES
AMIDE-BASED PROTECTING/RADICAL TRANSLOCATING (PRT) GROUPS - GENERATION OF RADICALS ADJACENT TO CARBONYLS BY 1,5-HYDROGEN TRANSFER-REACTIONS OF O-IODOANILIDES
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DOI：
10.1016/s0040-4020(01)90466-1
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发表时间：
1994-06-20
期刊：
影响因子：
2.1
通讯作者：
LIU, HT
中科院分区：
文献类型：
--
作者：
CURRAN, DP;YU, HS;LIU, HT
邻碘酰苯胺基团被证明是广泛适用于生成和随后的反应的自由基相邻的羧基。结果表明，该基团是迄今为止介绍的最好的“保护/自由基移位”（PRT）基团之一。除了其在自由基易位反应中的良好性能之外，它易于引入，在易位之前和之后都用作合理的保护基团，并且（经适当修饰）易于去除。
The o-iodoanilide group is shown to be broadly useful for the generation and subsequent reactions of radicals adjacent to carboxyl groups. The results indicate that this group is one of the best ''protecting/radical translocating'' (PRT) groups introduced to date. Beyond its good performance in radical translocation reactions, it is easy to introduce, serves as a reasonable protecting group both before and after the translocation, and (with appropriate modifications) is easy to remove.