Novelty-seeking behaviour and operant oral ethanol self-administration in Wistar rats
Novelty-seeking behaviour and operant oral ethanol self-administration in Wistar rats
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DOI：
10.1093/alcalc/36.6.525
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发表时间：
2001-11-01
影响因子：
2.8
通讯作者：
Kostowski, W
中科院分区：
文献类型：
--
作者：
Bienkowski, P;Koros, E;Kostowski, W
本研究的目的是探讨新的寻求行为和操作性口服乙醇自我管理的Wistar大鼠之间的关系。采用旷场和新奇物体测验评价新奇寻求能力。乙醇自我给药在操作程序中开始，其中在蔗糖存在下引入乙醇。32只大鼠中有18只成功地开始了8%（v/v）乙醇的加压。在开放领域（水平活动，rearings）或新的对象测试（与对象的接触次数，探索时间）评估的参数没有不同的发起和非发起的主题。此外，相关性分析表明，对新奇事物的反应并不能预测启动大鼠乙醇摄入量的个体差异。这些结果表明，在Wistar大鼠中，新奇寻求和操作性乙醇自我给药之间没有关系。
The aim of the present study was to investigate the relationship between novelty-seeking behaviour and operant oral ethanol self-administration in Wistar rats. The open field and novel object test was used to assess novelty-seeking. Ethanol self-administration was initiated in an operant procedure where ethanol was introduced in the presence of sucrose. Eighteen out of 32 rats were successfully initiated to lever-press for 8% (v/v) ethanol. None of the parameters assessed in the open field (horizontal activity, rearings) or novel object test (number of contacts with an object, exploration time) differed between the initiated and non-initiated subjects. In addition, correlational analysis revealed that response to novelty did not predict individual differences in ethanol intake in the initiated rats. These results suggest that there is no relationship between novelty-seeking and operant ethanol self-administration in Wistar rats.