Recent advances in the development of small-molecule CCR5 inhibitors for HIV.
Recent advances in the development of small-molecule CCR5 inhibitors for HIV.
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DOI：
10.2174/13895575110091277
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发表时间：
2010-10
期刊：
影响因子：
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通讯作者：
Tao Liu;Zhiyong Weng;Xiaowu Dong;Yongzhou Hu
中科院分区：
文献类型：
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作者：
Tao Liu;Zhiyong Weng;Xiaowu Dong;Yongzhou Hu
CCR5 (C-C chemokine receptor type 5) is a chemokine receptor that has been identified as a major HIV co-receptor in viral entry and therefore is a highly validated target for the development of new anti-HIV drugs. Here, we discuss the insights gained so far relevant to the development of small-molecule CCR5 inhibitors for the treatment of HIV, and highlight small-molecule CCR5 inhibitors that are currently under preclinical and clinical trials.
