Synthesis of antimalarial trioxanes via continuous photo-oxidation with 1O2 in supercritical CO2
Synthesis of antimalarial trioxanes via continuous photo-oxidation with 1O2 in supercritical CO2
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DOI：
10.1039/c2gc36711d
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发表时间：
2013-01-01
期刊：
影响因子：
9.8
通讯作者：
George, Michael W.
中科院分区：
文献类型：
--
作者：
Hall, Jessica F. B.;Bourne, Richard A.;George, Michael W.
烯丙醇氧化成过氧化氢是合成一系列螺二环、抗疟疾三恶烷的关键步骤。在这里，我们研究了烯丙醇在SCCO(2)中与O-1(2)的连续光氧化，作为传统方法的绿色替代方法，并研究了从容易获得的原料合成抗疟疾三噁烷的剩余两步。
The oxidation of an allylic alcohol to its hydroperoxides represents a key step in the synthesis of a series of spirobicyclic, antimalarial trioxanes. Herein, we investigate the continuous photo-oxidation of an allylic alcohol with O-1(2) in scCO(2), as a 'green' alternative to conventional methods, and examine the remaining two steps in the synthesis of antimalarial trioxanes from readily available starting materials.