Environmental factors and the age at onset in first episode psychosis
Environmental factors and the age at onset in first episode psychosis
复制标题
DOI：
10.1016/j.schres.2015.07.004
复制
发表时间：
2015-10-01
影响因子：
4.5
通讯作者：
Clarke, Mary
中科院分区：
文献类型：
--
作者：
O'Donoghue, Brian;Lyne, John;Clarke, Mary
目的：影响精神病性障碍发病年龄的因素可以为了解该疾病的诱发因素或致病因素提供有价值的见解。尽管是既定的风险因素，但尚不清楚移民身份、出生地、出生时的社会阶层和出生季节是否会影响精神障碍的发病年龄。这项研究旨在确定这些环境因素，除了大麻滥用和产科并发症，是否影响发病年龄。此外，我们调查了环境因素是否会对发病年龄产生累积效应。方法：数据来自两个首次发病的精神病（FEP）队列研究。诊断建立了使用DSM IV diagnosis.Results结构化临床访谈：发病年龄确定为555个人与FEP和发病时的中位年龄为27.3岁。有大麻滥用史的人发病年龄提前了近六年。有产科并发症史的趋势与发病年龄较年轻的2.7年，这是显着的精神病家族史的亚组。出生时的社会阶层、移民状况、出生地和出生季节与发病年龄无关。暴露于更多的环境因素与发病年龄较早相关。结论：大麻和产科并发症与发病年龄较早相关，暴露于多种环境因素似乎有累积效应。(C)2015 Elsevier B.V.版权所有。
Objective: Factors that influence the age at onset in psychotic disorders could provide valuable insights into precipitating or causative factors of the disorder. Despite being established risk factors, it is not yet known whether migration status, place of birth, social class at birth and season of birth influence the age at onset of psychotic disorders. This study aimed to determine whether these environmental factors, in addition to cannabis abuse and obstetric complications, influence the age at onset. Additionally, we investigated whether environmental factors could have a cumulative effect on the age at onset.Method: Data was obtained from two first episode of psychosis (FEP) cohort studies. Diagnosis was established using the Structured Clinical Interview for DSM IV diagnoses.Results: The age at onset was determined for 555 individuals with a FEP and the median age at onset was 27.3 years. Individuals with a history of cannabis abuse had an earlier age at onset by nearly six years. There was a trend for a history of obstetric complications to be associated with a younger age at onset by 2.7 years and this was significant in the subgroup with a family history of psychosis. Social class at birth, migration status, place of birth and season of birth were not associated with the age at onset. Exposure to a higher number of environmental factors was associated with an earlier age at onset.Conclusions: Cannabis and obstetric complications are associated with an earlier age at onset and there appears to be a cumulative effect of exposure to multiple environmental factors. (C) 2015 Elsevier B.V. All rights reserved.